PMID: 8610072Aug 1, 1995Paper

Transport of endocytosed material into melanin granules in cultured choroidal melanocytes of cattle--new insights into the relationship of melanosomes with lysosomes

Pigment Cell Research
Ulrich Schraermeyer

Abstract

Cultured choroidal melanocytes from cattle where incubated with gold labeled albumin. After phagocytosis of the labeled protein, the label appeared inside the melanin granules, as was observed under the electron microscope. Melanin granules associated with gold particles were also exocytosed into the culture medium by the melanocytes. The results of this study show that endosomes or phagosomes are transported from the cell surface of a melanocyte to the melanin granule. Therefore, melanin granules are part of the lysosomal degradation pathway. The possibility that albumin is degraded by proteases present in lysosomes and melanosomes and that the tyrosine released during degradation is used as a substrate by tyrosinase and thereby converted to melanin is discussed. The present study additionally shows that the choroidea of cattle can be used as a source for cell culture of melanocytes.

References

Mar 1, 1987·The Journal of Investigative Dermatology·R E BoissyR Halaban
Jan 1, 1988·Pigment Cell Research·R E BoissyJ J Nordlund
Mar 3, 1995·The Journal of Biological Chemistry·S DimentS J Orlow
Jul 1, 1994·Comparative Biochemistry and Physiology. Part C, Pharmacology, Toxicology & Endocrinology·U Schraermeyer
Feb 1, 1994·Pigment Cell Research·U Schraermeyer
Aug 1, 1993·Pigment Cell Research·U Schraermeyer
Jan 1, 1993·The Journal of Investigative Dermatology·S J OrlowS Pifko-Hirst
Feb 1, 1993·The Journal of Investigative Dermatology·B K ZhouS J Orlow
Apr 1, 1993·Experimental Cell Research·I C Le PooleP K Das
May 1, 1964·Archives of Ophthalmology·A J KROLL, T KUWABARA

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Citations

Feb 24, 2007·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Sylvie JulienUlrich Schraermeyer
Apr 27, 2007·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Monika Valtink, Katrin Engelmann
Jun 9, 2001·Critical Reviews in Immunology·W W Overwijk, N P Restifo
Dec 10, 1996·Proceedings of the National Academy of Sciences of the United States of America·D W ProvanceJ A Mercer
Nov 3, 2005·Traffic·Christa L BrownTrina A Schroer
Apr 11, 2008·Experimental Dermatology·Joo Hee AhnHee Young Kang
Jan 29, 2013·Pigment Cell & Melanoma Research·Brenda WattMichael S Marks
Mar 18, 2016·Cellular and Molecular Neurobiology·Guillaume van Niel
Apr 4, 2006·Experimental Eye Research·Ulrich SchraermeyerKarl-Ulrich Bartz-Schmidt
Aug 1, 1997·Experimental Eye Research·U SchraermeyerK Heimann

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