PMID: 3773502Oct 1, 1986Paper

Transport of fluid and biliary lipids in the canine gallbladder in experimental cholecystitis

The Journal of Surgical Research
J SvanvikL W Way

Abstract

In acute cholecystitis the cystic duct is usually obstructed by a gallstone and the gallbladder is often tensely distended with clear fluid. Because these findings suggest that fluid absorption in the gallbladder may be reversed in cholecystitis, we examined the effect of inflammation on the gallbladder mucosal function in dogs. In 20 dogs cholecystitis was induced by ligating the cystic duct and allowing inflammation to develop from bile stasis and the presence of a chronic indwelling cannula in the gallbladder. Every morning an aliquot of normal hepatic bile was infused into the gallbladder through a cannula in the gallbladder fundus. After either 4 or 24 hr the gallbladder contents were aspirated, the volume was measured, and the concentrations of bile acids, cholesterol, phospholipids, and protein were determined. Changes in volume were checked using [14C]PEG as a nonabsorbable tracer. A net absorption of fluid, bile acids, cholesterol, and phospholipids occurred during the first 24 to 48 hr after ligation of the cystic duct. Thereafter, fluid, cholesterol, and protein were secreted into the lumen, but absorption of bile acids continued. The lithogenic index of bile placed in the inflamed gallbladder was always greater when...Continue Reading

References

Jan 1, 1977·Prostaglandins·J R Wood, I F Stamford
Apr 5, 1972·Nature: New Biology·D J EvansD G Evans
Apr 30, 1971·Annals of the New York Academy of Sciences·G Kaley, R Weiner
Jan 1, 1971·The American Journal of Clinical Nutrition·J M Dietschy, H J Weis
Jan 1, 1960·Methods of Biochemical Analysis·P TALALAY

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Citations

Jul 1, 1989·Pflügers Archiv : European journal of physiology·F WehnerK U Petersen
Sep 28, 2000·Biochemical and Biophysical Research Communications·G MeyerG Bottà
Feb 19, 2013·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·J BeharM Carey
Mar 1, 1992·Prostaglandins, Leukotrienes, and Essential Fatty Acids·S I Myers
Mar 1, 1996·Toxicologic Pathology·S Molon-NoblotP Duprat
Oct 1, 1990·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J L TothS M Strasberg
Dec 1, 1987·The British Journal of Surgery·L JivegårdJ Svanvik
Mar 17, 2007·American Journal of Physiology. Gastrointestinal and Liver Physiology·A James MoserR J Bridges
Dec 17, 2020·PloS One·Jared A JaffeyAmy E DeClue
Sep 1, 1996·Primary Care·D I Giurgiu, J J Roslyn
Aug 20, 2021·The Journal of Small Animal Practice·J A Jaffey

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