PMID: 1202597Nov 1, 1975Paper

Transport of H2 and SF6 in the lung

Respiration Physiology
L M LacquetM Paiva

Abstract

The dead spaces for hydrogen and sulfur hexafluoride are predicted from the solution of a partial differential equation, applied to Weibel's morphometric data of the lung, and including longitudinal convection and diffusion coupled with instantaneous radial diffusion. Traces of H2 and SF6 were washed in and out of the lungs of two normal subjects. Dead spaces for both gases were calculated from the wash-out curves by a least squares analysis. Prediction and experiment agree in the case of H2. The model overestimates the dead space for SF6 particularly for large tidal volumes and for high breathing frequencies. Several factors which can contribute to this disagreement are considered. From simulation experiments it is evident, that the dead space for SF6 is highly sensitive to factors which influence molecular dispersion in the region of respiratory bronchioles. Cardiogenic mixing and some sort of flow-dependent mixing in this zone cannot be ruled out. However, the experimental data can also be explained by choosing another set of morphometric data for the alveolated airways.

References

Jun 1, 1974·Bulletin of Mathematical Biology·M R Davidson, J M Fitz-Gerald
Dec 1, 1974·Computers and Biomedical Research, an International Journal·M Paiva
Dec 1, 1972·Computers and Biomedical Research, an International Journal·M Paiva
Sep 1, 1972·The Bulletin of Mathematical Biophysics·P W SchererN M Greene
Dec 1, 1972·The Bulletin of Mathematical Biophysics·M Paiva, I Paiva-Veretennicoff
Sep 1, 1973·Respiration Physiology·H K ChangL E Farhi
Aug 1, 1971·Respiration Physiology·G CummingS B Preston
Oct 1, 1969·Respiration Physiology·R C Schroter, M F Sudlow
Jan 1, 1952·The Journal of Clinical Investigation·W S FOWLERS S KETY

Citations

Mar 1, 1978·Annals of Biomedical Engineering·N B Kindig, D R Hazlett
Nov 1, 1976·Respiration Physiology·R W MazzoneL E Farhi
Feb 1, 1979·Respiration Physiology·L A EngelY Fukuchi
Sep 1, 1981·Respiration Physiology·L A Engel, M Paiva
Jun 1, 1981·Respiration Physiology·M Paiva, L A Engel
Feb 1, 1985·Respiration Physiology·A M HaresnapeP M Hill
Oct 1, 1986·Respiration Physiology·A B CrawfordL A Engel
Apr 1, 1980·British Journal of Diseases of the Chest·K Horsfield
Dec 14, 2011·Journal of Applied Physiology·Sylvia VerbanckA van Muylem
May 8, 2000·Journal of Applied Physiology·M J EmeryM P Hlastala

Related Concepts

Diffusion
Fluorides
Hydrogen
Respiration
Respiratory Dead Space
Sulfur
Tidal Volume

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Lipidomics & Rhinovirus Infection

Lipidomics can be used to examine the lipid species involved with pathogenic conditions, such as viral associated inflammation. Discovered the latest research on Lipidomics & Rhinovirus Infection.

Glut1 Deficiency

Glut1 deficiency, an autosomal dominant, genetic metabolic disorder associated with a deficiency of GLUT1, the protein that transports glucose across the blood brain barrier, is characterized by mental and motor developmental delays and infantile seizures. Follow the latest research on Glut1 deficiency with this feed.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Alzheimer's Disease: MS4A

Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Laryngeal Neoplasms

Laryngeal Neoplasms occur in the Larynx and are typically associated with smoking and alcohol consumption. Discover the latest research on Laryngeal Neoplasms here.

Cell Atlas Along the Gut-Brain Axis

Profiling cells along the gut-brain axis at the single cell level will provide unique information for each cell type, a three-dimensional map of how cell types work together to form tissues, and insights into how changes in the map underlie health and disease of the GI system and its crosstalk with the brain. Disocver the latest research on single cell analysis of the gut-brain axis here.