Transport of information along unidimensional layered networks of dissociated hippocampal neurons and implications for rate coding.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Ofer Feinerman, Elisha Moses

Abstract

The ability of synchronous population activity in layered networks to transmit a rate code is a focus of recent debate. We investigate these issues using a patterned unidimensional hippocampal culture. The network exhibits population bursts that travel its full length, with the advantage that signals propagate along a clearly defined path. The amplitudes of activity are measured using calcium imaging, a good approximate of population rate code, and the distortion of the signal as it travels is analyzed. We demonstrate that propagation along the line is precisely described by information theory as a chain of Gaussian communication channels. The balance of excitatory and inhibitory synapses is crucial for this transmission. However, amplitude information carried along this layered neuronal structure fails within 3 mm, approximately 10 mean axon lengths, and is limited by noise in the synaptic transmission. We conclude that rate codes cannot be reliably transmitted through long layered networks.

Citations

Jan 27, 2009·Journal of Computational Neuroscience·E Alvarez-Lacalle, E Moses
Sep 6, 2008·Proceedings of the National Academy of Sciences of the United States of America·Jordi SorianoElisha Moses
Apr 26, 2012·PLoS Computational Biology·Raoul-Martin Memmesheimer, Marc Timme
Mar 15, 2016·Frontiers in Bioengineering and Biotechnology·Sankaraleengam AlagapanThomas B DeMarse
Dec 17, 2014·PLoS Computational Biology·Sven JahnkeMarc Timme
Dec 23, 2015·PLoS Computational Biology·Takuya IsomuraYasuhiko Jimbo
Apr 27, 2010·Chemical Society Reviews·Evgeny Katz, Vladimir Privman
Dec 13, 2006·Physical Review Letters·Ilan BreskinTsvi Tlusty
Jul 4, 2008·Journal of Neurophysiology·Takuya SasakiYuji Ikegaya
Oct 2, 2009·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Malgorzata TuralskaPaolo Grigolini
Nov 4, 2015·Journal of Neural Engineering·Takuya IsomuraYasuhiko Jimbo
Sep 5, 2019·Nature Communications·Jérémie BarralAlex D Reyes
Feb 5, 2011·Lab on a Chip·Ashwin VishwanathanHenry C Zeringue
Dec 30, 2015·Advanced Healthcare Materials·Shotaro YoshidaShoji Takeuchi
Dec 14, 2018·Bioinspiration & Biomimetics·Hector G Vasquez, Giovanni Zocchi
Jul 30, 2010·Journal of Neurophysiology·Shimshon JacobiElisha Moses
Nov 18, 2018·Scientific Reports·Takuya Isomura, Karl Friston
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Apr 10, 2009·The Journal of Physical Chemistry. B·Vladimir PrivmanEvgeny Katz
Jul 9, 2009·The Journal of Physical Chemistry. B·Dmitriy MelnikovEvgeny Katz

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