PMID: 6408605Apr 1, 1983Paper

Transport of L-lysine by rat renal brush border membrane vesicles

Pflügers Archiv : European journal of physiology
B StiegerH Murer

Abstract

L-3H-lysine uptake into brush border membrane vesicles was measured by a rapid filtration technique. A significant binding of L-lysine at the vesicle interior was observed. Extrapolating initial linear uptake to zero incubation time did not indicate binding of the amino acid to the external membrane surface. Sodium stimulated the L-lysine uptake specifically. Experiments in the presence of potassium/valinomycin induced diffusion potentials, and experiments with a potential sensitive fluorescent dye documented an electrogenic uptake mechanism for L-lysine only in the presence of sodium. Sodium independent uptake proceeds via an electroneutral pathway. Transstimulation experiments show carrier mediated uptake in the presence and absence of sodium. An outwardly directed proton-gradient stimulated L-lysine uptake in the presence and absence of sodium. Saturation of L-lysine uptake was observed in the presence and absence of sodium. In the absence of sodium, L-lysine uptake was inhibited by L-arginine, L-cystine, L-phenylalanine and L-methionine. The sodium dependent uptake was inhibited by L-arginine and L-cysteine; small inhibition by L-phenylalanine was observed. In the presence or absence of sodium, L-lysine uptake was inhibited...Continue Reading

References

Jan 1, 1979·Annual Review of Physiology·K J Ullrich
Apr 15, 1978·The Biochemical Journal·W HaaseR Kinne
Dec 1, 1978·Archives of Biochemistry and Biophysics·D Busse
Jan 1, 1974·Pflügers Archiv : European journal of physiology·K J UllrichS Klöss
Jan 1, 1972·Pflügers Archiv : European journal of physiology·S Silbernagl, P Deetjen
Jun 4, 1973·Pflügers Archiv : European journal of physiology·S Silbernagl, P Deetjen
Mar 17, 1967·Science·L E RosenbergS Segal
May 1, 1982·Pflügers Archiv : European journal of physiology·I Samarzija, E Frömter
Mar 1, 1983·Pflügers Archiv : European journal of physiology·J BiberH Murer
Jan 1, 1983·The Journal of Membrane Biology·B StiegerH Murer
Jan 1, 1982·The Journal of Membrane Biology·A K MircheffE M Wright
Feb 8, 1982·Biochimica Et Biophysica Acta·M R Hammerman
May 1, 1982·Pflügers Archiv : European journal of physiology·I Samarzija, E Frömter
Aug 1, 1981·Archives of Biochemistry and Biophysics·S A Hilden, B Sacktor
Feb 15, 1981·The Biochemical Journal·P D McNamaraS Segal
Jun 20, 1980·Biochimica Et Biophysica Acta·G BurckhardtH Murer

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Citations

Sep 1, 1989·Pflügers Archiv : European journal of physiology·J S SchweglerS Silbernagl
Apr 1, 1983·Pflügers Archiv : European journal of physiology·G CassanoH Murer
Jan 30, 1989·Biochimica Et Biophysica Acta·C P Wheeler, D L Yudilevich
Jan 1, 1987·Neurochemistry International·L C Mokrasch
Mar 23, 2000·European Journal of Biochemistry·S BerardiS Krähenbühl
Sep 1, 1989·Kidney International·I Zelikovic, R W Chesney
Aug 1, 1986·Kidney International·H Murer, P Gmaj
Dec 12, 2017·Journal of Nutrition and Metabolism·Rondo P MiddletonJim Kaput
Mar 1, 1983·Pflügers Archiv : European journal of physiology·J BiberH Murer
Jan 16, 2008·Physiological Reviews·Stefan Bröer
Sep 1, 1991·The American Journal of Physiology·J H SweiryG E Mann
Sep 3, 1984·Biochimica Et Biophysica Acta·S Bannai
Jul 10, 1987·Biochimica Et Biophysica Acta·M A BowringS Segal
Nov 15, 1989·Biochemical and Biophysical Research Communications·B M RotoliG C Gazzola
Mar 23, 2010·European Journal of Pharmacology·Regula SchürchStephan Krähenbühl

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