Transport of nanoparticulate material in self-assembled block copolymer micelle solutions and crystals

Faraday Discussions
Vicki A Cheng, Lynn M Walker

Abstract

Water soluble poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) [PEO-PPO-PEO] triblock copolymers self-assemble into thermoreversible micellar crystals comprised of periodically spaced micelles. The micelles have PPO cores surrounded by hydrated PEO coronas and the dimensions of the unit cell of the organized micelles is on the order of several to tens of nanometers. Fluorescence recovery after photobleaching (FRAP) is used to quantify nanoparticle transport in these nanostructured polymer micelle systems. Diffusivity of bovine serum albumin (BSA, Dh ∼ 7 nm) is quantified across a wide range of polymer, or micelle, concentrations covering both the disordered fluid as well as the structured micellar crystal to understand the effects of nanoscale structure on particle transport. Measured particle diffusivity in these micellar systems is reduced by as much as four orders of magnitude when compared to diffusivity in free solution. Diffusivity in the disordered micellar fluid is best understood in terms of diffusion through a polymeric solution, while transport in the structured micellar phase is possibly due to hopping between interstitial sites. These results not only show that the nanoscale structures of the micelle...Continue Reading

References

Sep 1, 1992·Protein Science : a Publication of the Protein Society·R Bhat, S N Timasheff
Mar 1, 1996·Biophysical Journal·J Tong, J L Anderson
Feb 1, 1996·Biophysical Journal·E M JohnsonW M Deen
Jan 1, 1961·Biophysical Journal·M A LAUFFER
Feb 12, 2004·Methods in Enzymology·Robert D PhairTom Misteli
Jan 7, 2005·The Journal of Chemical Physics·V CastellettoT A Waigh
Jan 7, 2006·The Journal of Chemical Physics·H YardimciR L Leheny
Apr 17, 2008·The European Physical Journal. E, Soft Matter·D C Pozzo, L M Walker
Oct 11, 2008·Journal of Colloid and Interface Science·Liem Chau Pham TrongAlain Ponton
Jan 1, 1990·Annual Review of Physical Chemistry·F S Bates, G H Fredrickson
Nov 8, 2011·Macromolecules·Li-Heng CaiMichael Rubinstein
Feb 19, 2015·Macromolecules·Li-Heng CaiMichael Rubinstein
Oct 3, 2015·Physical Review Letters·Sudipta GuptaDieter Richter
Oct 16, 2015·Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics·Ameur LouhichiLaurence Ramos
Jun 6, 2005·Advanced Materials·M R BockstallerE L Thomas

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