Transport of neutral solute across articular cartilage: the role of zonal diffusivities

Journal of Biomechanical Engineering
V ArbabiA A Zadpoor

Abstract

Transport of solutes through diffusion is an important metabolic mechanism for the avascular cartilage tissue. Three types of interconnected physical phenomena, namely mechanical, electrical, and chemical, are all involved in the physics of transport in cartilage. In this study, we use a carefully designed experimental-computational setup to separate the effects of mechanical and chemical factors from those of electrical charges. Axial diffusion of a neutral solute Iodixanol into cartilage was monitored using calibrated microcomputed tomography micro-CT images for up to 48 hr. A biphasic-solute computational model was fitted to the experimental data to determine the diffusion coefficients of cartilage. Cartilage was modeled either using one single diffusion coefficient (single-zone model) or using three diffusion coefficients corresponding to superficial, middle, and deep cartilage zones (multizone model). It was observed that the single-zone model cannot capture the entire concentration-time curve and under-predicts the near-equilibrium concentration values, whereas the multizone model could very well match the experimental data. The diffusion coefficient of the superficial zone was found to be at least one order of magnitude ...Continue Reading

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Citations

Aug 9, 2020·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Abhisek BhattaraiMikael J Turunen
Jun 15, 2018·Nature Reviews. Rheumatology·Chris D DiDomenicoLawrence J Bonassar
Sep 26, 2020·Frontiers in Cell and Developmental Biology·Mateus Oliveira SilvaKathryn S Stok
Jan 4, 2019·Biomechanics and Modeling in Mechanobiology·Tanvir R FaisalYasin Y Dhaher

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