Transport vesicle docking: SNAREs and associates

Annual Review of Cell and Developmental Biology
S R Pfeffer

Abstract

Proteins that function in transport vesicle docking are being identified at a rapid rate. So-called v- and t-SNAREs form the core of a vesicle docking complex. Additional accessory proteins are required to protect SNAREs from promiscuous binding and to deprotect SNAREs under conditions in which transport vesicle docking should occur. Because access to SNAREs must be regulated, other proteins must also contain specificity determinants to accomplish delivery of transport vesicles to their distinct and specific membrane targets.

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Methods Mentioned

BETA
immunoprecipitation
GTPase
GTPases
two-hybrid
immunoprecipitations

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