Transportation of a commercial premixed intravenous insulin product through a pneumatic tube system.

American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists
Noah LejaJeff Hurren

Abstract

Delivery of insulin products via pneumatic tubes is often avoided in health systems, as agitation may cause insulin proteins to destabilize, resulting in loss of function through denaturation, aggregation, or other processes. The actual loss of potency due to delivery via pneumatic tubes has not been reported for new, ready-to-use insulin products. Samples were drawn from 7 commercial intravenous (IV) bags containing a 100 units/100 mL premixed solution of regular insulin in sodium chloride injection (Myxredlin, Baxter). The bags were then exposed to 7 unique long-distance pneumatic tube routes. The posttransportation bags were visually inspected for evidence of foaming. Samples were drawn from the posttransportation bags and insulin concentrations were analyzed via an enzyme immunoassay and compared to pretransportation concentrations. All seven posttransportation insulin samples were within 10% of their respective pretransportation sample. No foaming was observed in any of the Myxredlin bags after transportation through the pneumatic tube system. Transporting 100 unit/100 mL Myxredlin i.v. bags through a pneumatic tube system does not result in a clinically significant loss of potency. Therefore, delivery of this drug product...Continue Reading

References

Nov 1, 1989·Pharmaceutical Research·M C ManningR T Borchardt
May 1, 1983·Diabetes·W D LougheedJ R Clement
Aug 8, 2015·Diabetes Spectrum : a Publication of the American Diabetes Association·Janet L Kelly
Nov 18, 2017·Interface Focus·Karolina L ZapadkaSophie E Jackson
Jun 12, 2018·International Journal of Pharmaceutics·Mohsen AkbarianReza Yousefi

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