Transporter-mediated drug delivery: recent progress and experimental approaches

Drug Discovery Today
Yoshimichi Sai, Akira Tsuji

Abstract

A comprehensive list of drug transporters has recently become available as a result of extensive genome analysis, as well as membrane physiology and molecular biology studies. This review covers recent progress in identification and characterization of drug transporters, illustrative cases of successful drug delivery to, or exclusion from, target organs via transporters, and novel experimental approaches to therapeutics using heterologously transduced transporters in tissues. We aim to provide clues that could lead to efficient strategies for the use of transporters to deliver drugs and/or to optimize lead compounds.

References

Jan 1, 1991·European Journal of Clinical Pharmacology·H Y Pan
Aug 1, 1990·The Biochemical Journal·J DyerS P Shirazi-Beechey
Mar 1, 1994·Nihon yakurigaku zasshi. Folia pharmacologica Japonica·I YakuoT Karasawa
Nov 1, 1995·Pharmaceutical Research·I TamaiA Tsuji
Jul 1, 1996·Pharmaceutical Research·A Tsuji, I Tamai
Dec 1, 1996·The Journal of Membrane Biology·H Daniel
Feb 7, 1998·The Journal of Biological Chemistry·C S TempleJ R Bronk
Apr 29, 1998·Antimicrobial Agents and Chemotherapy·S YoshizumiK Yamaguchi
Jun 4, 1998·Biochemical and Biophysical Research Communications·M E GanapathyF H Leibach
Aug 29, 1998·The Journal of Biological Chemistry·F DöringH Daniel
Oct 1, 1998·Biochemical and Biophysical Research Communications·P V BalimaneP J Sinko
Apr 3, 1999·Journal of Pharmaceutical Sciences·I TamaiA Tsuji
May 5, 1999·Pharmaceutical Research·A SoldnerL Z Benet
Oct 16, 1999·Journal of Controlled Release : Official Journal of the Controlled Release Society·A Tsuji
Jun 30, 2000·Biochemical and Biophysical Research Communications·I TamaiA Tsuji
Sep 27, 2000·International Journal of Cancer. Journal International Du Cancer·T NakanishiA Tsuji
Oct 4, 2000·Journal of Pharmaceutical Sciences·I Tamai, A Tsuji
Oct 29, 2000·American Journal of Physiology. Renal Physiology·T TeradaK Inui
Dec 21, 2000·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·A Seelig, E Landwojtowicz
Feb 13, 2001·The American Journal of Pathology·D A GronebergA Fischer
Apr 18, 2001·The Journal of Clinical Investigation·T HatanakaM E Ganapathy
Dec 14, 2001·AAPS PharmSci·H K Han, G L Amidon
Feb 16, 2002·Biochemical and Biophysical Research Communications·Takahiro HatanakaVadivel Ganapathy
Jan 1, 2003·Biochimica Et Biophysica Acta·B Hagenbuch, P J Meier
Jan 1, 2003·Biochimica Et Biophysica Acta·Mitsuru SugawaraKatsumi Miyazaki
Feb 14, 2003·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Cuiping ChenJae S Lee
Mar 22, 2003·The Journal of Pharmacology and Experimental Therapeutics·Hidekazu ToyobukuAkira Tsuji
May 2, 2003·The Journal of Pharmacology and Experimental Therapeutics·Daisuke KobayashiIkumi Tamai
Jul 19, 2003·Pharmacological Reviews·Naomi MizunoYuichi Sugiyama
Sep 23, 2003·Journal of Pharmaceutical Sciences·Joseph W PolliCosette J Serabjit-Singh
Oct 25, 2003·The Journal of Pharmacology and Experimental Therapeutics·Johan W Jonker, Alfred H Schinkel
Nov 12, 2003·The Journal of Pharmacology and Experimental Therapeutics·Takashi NozawaIkumi Tamai

❮ Previous
Next ❯

Citations

Oct 16, 2008·Biochemistry·Cindy A Puckett, Jacqueline K Barton
Jan 9, 2013·Journal of Chemical Information and Modeling·Danielle NewbyTaravat Ghafourian
Mar 1, 2008·Nature Reviews. Drug Discovery·Paul D Dobson, Douglas B Kell
Aug 19, 2007·Expert Opinion on Drug Metabolism & Toxicology·Florian NigschSilvia Miret
Oct 16, 2014·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Arik DahanShimon Ben-Shabat
Apr 9, 2014·Expert Opinion on Drug Metabolism & Toxicology·Parvin Zakeri-Milani, Hadi Valizadeh
Jun 6, 2008·Expert Opinion on Drug Delivery·Leonid Kagan, Amnon Hoffman
Apr 25, 2008·Expert Opinion on Drug Metabolism & Toxicology·Christoph Funk
May 20, 2015·Journal of Pharmaceutical Sciences·Shinji SakumaKohsaku Kawakami
Nov 19, 2009·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·P SharmaD Surry
Jan 14, 2012·Journal of Medicinal Chemistry·David J HugginsBruce Tidor
Jul 26, 2008·International Journal of Pharmaceutics·Uwais M SyedHua Zhu
Sep 17, 2009·Journal of Veterinary Pharmacology and Therapeutics·M M Al-BatainehR Gehring
Apr 18, 2008·The Journal of Pharmacy and Pharmacology·Matthias BrandschEva Bosse-Doenecke
Jun 1, 2011·Journal of Veterinary Pharmacology and Therapeutics·M M Al-BatainehR Gehring
Aug 27, 2014·Molecular Reproduction and Development·Tufan GökirmakAmro Hamdoun
Aug 1, 2006·Journal of Controlled Release : Official Journal of the Controlled Release Society·Tomoko SugiuraAkira Tsuji
Dec 27, 2005·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Yukio KatoAkira Tsuji
Jan 3, 2006·Cancer Letters·P BorstK van de Wetering
Jan 1, 2012·Scientifica·Jose J G Marin
Jun 3, 2015·Molecular Pharmaceutics·Andrea TestaPradeep Sharma
May 20, 2005·The Journal of Pharmacy and Pharmacology·Takashi MizumaMasahiro Hayashi
May 14, 2008·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Ken GrimeRobert J Riley
Jul 12, 2017·Scientific Reports·Matthew J FoulkesStephen A Renshaw
Aug 10, 2006·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Chizuru WatanabeAkira Tsuji

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antiparasitics

Antiparasitics are medications which are indicated for the treatment of parasitic diseases. Discover the latest research on antiparasitics here.

Cancer Metabolism

In order for cancer cells to maintain rapid, uncontrolled cell proliferation, they must acquire a source of energy. Cancer cells acquire metabolic energy from their surrounding environment and utilize the host cell nutrients to do so. Here is the latest research on cancer metabolism.

Related Papers

European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences
Yoshihisa ShitaraYuichi Sugiyama
© 2021 Meta ULC. All rights reserved