Transporters Involved in Metformin Pharmacokinetics and Treatment Response

Journal of Pharmaceutical Sciences
Xiaomin Liang, Kathleen M Giacomini

Abstract

Metformin, widely used as first-line treatment for type 2 diabetes, exists primarily as a hydrophilic cation at physiological pHs. As such, membrane transporters play a substantial role in its absorption, tissues distribution, and renal elimination. Multiple organic cation transporters are determinants of the pharmacokinetics of metformin, and many of them are important in its pharmacological action, as mediators of metformin entry into target tissues. Furthermore, a recent genome-wide association study in a large multi-ethnic population implicated polymorphisms in SLC2A2, encoding the glucose transporter, GLUT2, as important determinants of response to metformin. Here, we describe the key transporters associated with metformin pharmacokinetics and response.

References

Sep 1, 1979·European Journal of Clinical Pharmacology·P J PentikäinenA Penttilä
Nov 1, 1995·Journal of Clinical Pharmacology·N C SambolM G Cogan
Jul 20, 2002·The Journal of Pharmacology and Experimental Therapeutics·De-Sheng WangYuichi Sugiyama
Apr 30, 2003·Proceedings of the National Academy of Sciences of the United States of America·Yan ShuUNKNOWN Pharmacogenetics Of Membrane Transporters Investigators
Sep 28, 2004·The Journal of Biological Chemistry·Karen EngelJoanne Wang
Aug 16, 2005·Molecular Pharmacology·Karen Engel, Joanne Wang
Nov 3, 2005·Biochemical Pharmacology·Johanna MüllerMatthias Brandsch
Nov 8, 2005·Drug Metabolism and Pharmacokinetics·Naoko KimuraKen-Ichi Inui
Oct 5, 2006·American Journal of Physiology. Renal Physiology·Li XiaJoanne Wang
Nov 23, 2006·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·K BleasbyJ G Slatter
May 4, 2007·The Journal of Clinical Investigation·Yan ShuKathleen M Giacomini
Jun 30, 2007·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Mingyan ZhouJoanne Wang
Jul 5, 2007·Clinical Pharmacology and Therapeutics·Y ShuK M Giacomini
May 7, 2008·Drug Metabolism and Disposition : the Biological Fate of Chemicals·William R ProctorDhiren R Thakker
Dec 17, 2008·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Soichiro MatsushimaYuichi Sugiyama
Jan 28, 2009·The Pharmacogenomics Journal·Ying ChenKathleen M Giacomini
Jun 2, 2009·Pharmacogenetics and Genomics·Ying ChenKathleen M Giacomini
Jun 6, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Narender NathShailendra Giri
Jan 13, 2010·The Journal of Pharmacology and Experimental Therapeutics·Sumito ItoYuichi Sugiyama
Jan 19, 2011·Clinical Pharmacokinetics·Garry G GrahamKenneth M Williams
Oct 1, 2011·Clinical Pharmacology and Therapeutics·J H ChoiK M Giacomini
Mar 13, 2012·Drug Metabolism and Disposition : the Biological Fate of Chemicals·J William HigginsMaciej J Zamek-Gliszczynski
Jun 23, 2012·Pharmacogenetics and Genomics·Li GongTeri E Klein
Oct 9, 2012·Advanced Drug Delivery Reviews·Margarida EstudanteLeslie Z Benet
Nov 28, 2012·Archives of Medical Science : AMS·Arrigo F G CiceroSibel Ertek
Dec 27, 2012·Clinical Pharmacology and Therapeutics·S L StockerK M Giacomini
Feb 19, 2013·Diabetology & Metabolic Syndrome·Lilian Beatriz Aguayo Rojas, Marilia Brito Gomes
Feb 26, 2013·The AAPS Journal·Hideyuki Motohashi, Ken-ichi Inui
May 15, 2013·Journal of Pharmaceutical Sciences·Noritaka NakamichiYukio Kato
Jan 8, 2014·Nature Reviews. Endocrinology·Ida Pernicova, Márta Korbonits
Jan 8, 2015·The Journal of Pharmacology and Experimental Therapeutics·Tianxiang Kevin HanDhiren R Thakker

❮ Previous
Next ❯

Citations

Jan 21, 2018·British Journal of Clinical Pharmacology·Ana Beatriz SantoroGuilherme Suarez-Kurtz
Oct 31, 2018·Expert Opinion on Drug Metabolism & Toxicology·Paul ChanZhong-Min Liu
Jul 26, 2019·BioFactors·Alena PecinováTomáš Mráček
Oct 12, 2018·Current Diabetes Reviews·Maria M Adeva-AndanyMatilde Vila-Altesor
Sep 5, 2020·Cancers·Samson Mathews SamuelDietrich Büsselberg
Jul 4, 2019·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Donglu ZhangS Cyrus Khojasteh
Aug 24, 2019·Nature Reviews. Endocrinology·Marc ForetzBenoit Viollet
Sep 24, 2020·International Journal of Molecular Sciences·Yulia A NasykhovaAndrey S Glotov
Sep 16, 2020·Diabetes Therapy : Research, Treatment and Education of Diabetes and Related Disorders·Zhiwei ZengTao Sun
Apr 29, 2019·Clinical Pharmacokinetics·Merel van NulandJos H Beijnen
Nov 26, 2019·The American Journal of Clinical Nutrition·Jim Kaput
May 14, 2020·Analytical Cellular Pathology (Amsterdam)·Chidiebere V UgwuezeBasil C Ezeokpo
Apr 24, 2019·Advanced Pharmaceutical Bulletin·Amr Ahmed El-ArabeyWafa Ali Eltayb
Nov 10, 2020·Expert Review of Neurotherapeutics·Sarah DemaréPaul Fernyhough
Jun 28, 2020·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Benjamin ChevalierAlexandre Escande
Jan 16, 2021·Journal of Pharmaceutical Sciences·Melissa MetryJames E Polli
Jan 13, 2021·Biochemical Pharmacology·Minghao ChenLing Ye
Dec 15, 2020·British Journal of Clinical Pharmacology·Geoffrey T Tucker, Carl A Wesolowski
Feb 17, 2021·The FEBS Journal·Huimin ZhangJörg J Goronzy
Feb 23, 2021·European Journal of Pharmacology·Michelle Jaromy, Joshua D Miller
Feb 21, 2021·The Journal of Investigative Dermatology·Paul SchilfChristian D Sadik
May 1, 2021·Biomedicines·Marek DrozdzikStefan Oswald
May 7, 2021·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Xian-Mei SongRui-Feng Liang
Mar 11, 2021·American Journal of Physiology. Cell Physiology·Leena P Bharath, Barbara S Nikolajczyk
Jul 3, 2021·International Journal of Molecular Sciences·Isabella PanfoliDavide Maggi
Jul 3, 2021·Pharmaceuticals·Yoo-Seong Jeong, William J Jusko
Jul 27, 2021·Clinical Pharmacokinetics·Janis KurlovicsEgils Stalidzans

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.