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Transposable elements as a potent source of diverse cis -regulatory sequences in mammalian genomes

Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences

Feb 23, 2020

Vasavi Sundaram, Joanna Wysocka

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PubMed

Abstract

Eukaryotic gene regulation is mediated by cis-regulatory elements, which are embedded within the vast non-coding genomic space and recognized by the transcription factors in a sequence- and context-dependent manner. A large proportion of eukaryotic genomes, including at least half of th...read more

Mentioned in this Paper

Regulatory Sequences, Nucleic Acid
Environment
Analysis
DNA Transposable Elements
Embryonic Development
Genes, Regulator
Gene Silencing
Species
Gene Regulatory Networks
Promoter
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Transposable elements as a potent source of diverse cis -regulatory sequences in mammalian genomes

Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences

Feb 23, 2020

Vasavi Sundaram, Joanna Wysocka

PMID: 32075564

DOI: 10.1098/rstb.2019.0347

Abstract

Eukaryotic gene regulation is mediated by cis-regulatory elements, which are embedded within the vast non-coding genomic space and recognized by the transcription factors in a sequence- and context-dependent manner. A large proportion of eukaryotic genomes, including at least half of th...read more

Mentioned in this Paper

Regulatory Sequences, Nucleic Acid
Environment
Analysis
DNA Transposable Elements
Embryonic Development
Genes, Regulator
Gene Silencing
Species
Gene Regulatory Networks
Promoter

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Transposons can replicate and spread through the host’s genome and therefore be used as a genetic tool for analysis of gene function. Discover the latest research on the use of transposons for gene editing here.

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