Transposable elements, circular RNAs and mitochondrial transcription in age-related genomic regulation.

Development
Juan I BravoBérénice A Benayoun

Abstract

Our understanding of the molecular regulation of aging and age-related diseases is still in its infancy, requiring in-depth characterization of the molecular landscape shaping these complex phenotypes. Emerging classes of molecules with promise as aging modulators include transposable elements, circRNAs and the mitochondrial transcriptome. Analytical complexity means that these molecules are often overlooked, even though they exhibit strong associations with aging and, in some cases, may directly contribute to its progress. Here, we review the links between these novel factors and age-related phenotypes, and we suggest tools that can be easily incorporated into existing pipelines to better understand the aging process.

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Citations

Mar 7, 2021·Animals : an Open Access Journal From MDPI·Pablo Jesús Marín-García, Lola Llobat
Apr 6, 2021·Frontiers in Cell and Developmental Biology·Jingyi CaiZhihe Zhao
May 30, 2021·Experimental Gerontology·Francisco Alejandro Lagunas-Rangel
Oct 10, 2021·FEBS Letters·Camille Ravel-GodreuilJulia Fuchs

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