PMID: 11315188Apr 21, 2001Paper

Transposase and cointegrase: specialized transposition proteins of the bacterial insertion sequence IS21 and related elements

Cellular and Molecular Life Sciences : CMLS
B Berger, D Haas

Abstract

The bacterial insertion sequence IS21 shares with many insertion sequences a two-step, reactive junction transposition pathway, for which a model is presented in this review: a reactive junction with abutted inverted repeats is first formed and subsequently integrated into the target DNA. The reactive junction occurs in IS21-IS21 tandems and IS21 minicircles. In addition, IS21 shows a unique specialization of transposition functions. By alternative translation initiation, the transposase gene codes for two products: the transposase, capable of promoting both steps of the reactive junction pathway, and the cointegrase, which only promotes the integration of reactive junctions but with higher efficiency. This review also includes a survey of the IS21 family and speculates on the possibility that other members present a similar transpositional specialization.

Citations

Dec 6, 2006·Antimicrobial Agents and Chemotherapy·Corinna KehrenbergStefan Schwarz
Oct 31, 2006·Applied and Environmental Microbiology·Simy L BuckwoldAugusto A Franco
Apr 7, 2005·Applied and Environmental Microbiology·Yoshiyuki OhtsuboMasataka Tsuda
Dec 19, 2006·Journal of Bacteriology·Masaki ShintaniHideaki Nojiri
Jan 14, 2010·Critical Reviews in Biochemistry and Molecular Biology·Alison Burgess HickmanFred Dyda
Sep 10, 2010·Anaerobe·Gena D TribbleCharles J Smith
Aug 19, 2005·Journal of Biotechnology·Khalid Ibrahim SallamTomohiro Tamura
Aug 16, 2015·Cell·Chi-Lin TsaiJohn A Tainer
Feb 7, 2014·FEMS Microbiology Reviews·Patricia SiguierMick Chandler
Aug 21, 2013·Mobile Genetic Elements·Mélanie V TrudelSteve J Charette
Sep 1, 2005·International Journal of Medical Microbiology : IJMM·Andrey GolubovAlexander Rakin
Apr 13, 2017·Microbial Biotechnology·Rohola HosseiniJohannes H de Winde
Sep 11, 2003·Clinical Orthopaedics and Related Research·Bruce H ZiranRonald A Hall
Jun 7, 2017·Current Microbiology·Guangxiang CaoXiuhua Pang
Mar 25, 2021·Mobile DNA·Alessandro VaraniMichael Chandler
Jun 25, 2015·Microbiology Spectrum·Patricia SiguierMick Chandler
Aug 20, 2021·Microbiology Resource Announcements·Pascal HilaireStanislas C Morand

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