Transposition of great arteries is associated with increased carotid artery stiffness

Hypertension
Beatrix MersichMark Kollai

Abstract

Transposition of great arteries is the consequence of abnormal aorticopulmonary septation. Animal embryonic data indicate that septation and elastogenesis are related events, but human and clinical data are not available. We tested the hypothesis that large artery elastic function was impaired in patients with transposition of great arteries. We studied 34 patients aged 9 to 19 years, 12+/-3 years after atrial switch operation; 14 patients aged 7 to 9 years, 8+/-1 years after arterial switch operation; and 108 healthy control subjects matched for age. Carotid artery diastolic diameter and pulsatile distension were determined by echo wall-tracking; carotid blood pressure was measured by tonometry. Systolic pressure was higher and diastolic pressure was lower in patients than in controls. Patients with atrial and arterial switch repair were compared with their respective controls by 2-factor ANOVA. For patients with atrial switch repair versus control, stiffness index beta was 4.9+/-1.5 versus 3.1+/-1.0 (P<0.001); for patients witch arterial switch versus control, stiffness index beta was 3.8+/-1.1 versus 2.1+/-0.6 (P<0.001). Similar differences were observed for carotid compliance, distensibility, and incremental elastic modulus...Continue Reading

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Citations

Dec 25, 2010·Heart and Vessels·Andrea LászlóPéter Studinger
May 7, 2008·Pediatric Research·Giacomo D SimonettiMarkus G Mohaupt
Mar 10, 2009·The American Journal of Cardiology·Shobha NatarajanTheresa A Tacy
Sep 17, 2014·The Journal of Thoracic and Cardiovascular Surgery·Giovanni BiglinoAndrew M Taylor
Sep 21, 2011·International Journal of Cardiology·Magalie LadouceurElie Mousseaux
Jun 29, 2013·Archives of Cardiovascular Diseases·Magalie LadouceurDamien Bonnet
Apr 28, 2010·Korean Circulation Journal·Yiu-Fai Cheung
Oct 21, 2016·Journal of cardiology·Olga TrojnarskaStefan Grajek
Jul 31, 2010·American Journal of Hypertension·Bryan RossCharles V Rohlicek
Oct 24, 2017·European Journal of Preventive Cardiology·Anna-Luisa HäckerJan Müller
Mar 4, 2021·Journal of Hypertension·Melanie M ClarkeJonathan P Mynard
Aug 24, 2021·Heart, Lung & Circulation·Kieran SandhuJonathan P Mynard

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