The objective of this study is to highlight the factors that may affect prenatal diagnosis of transposition of the great arteries (TGA) in order to improve it. This is a retrospective study performed between 2004 and 2009 in the maternity units from North of France. We identified a total of 68 cases of TGA (isolated or associated with only VSD or coarctation of aorta), of which 32 (47.1%) had prenatal diagnosis (PND+) and 36 did not (PND-). Maternal characteristics and ultrasound factors were studied in relation to PND. Maternal weight and body mass index were significantly higher in the PND- group (70.4 kg and 26.5 kg/m(2) vs 63.6 kg and 23.6 kg/m(2) , respectively). Maternal obesity (body mass index >30) was significantly more frequent in the PND- group (27.8% vs 12.5%). More than a quarter of TGA (28.1%) were diagnosed during the third trimester. Obesity is the main cause of missed PND of TGA. Obese patients with suboptimal prenatal scans may benefit from reassessment of fetal cardiac anatomy and/or from referral for fetal echocardiography.
Fetal echocardiography: factors that influence imaging of the fetal heart during the second trimester of pregnancy
Management of the fetus with a correctable malformation in Paris maternity units: evolution 1985-1994
Detection of transposition of the great arteries in fetuses reduces neonatal morbidity and mortality
Comparison of outcome when hypoplastic left heart syndrome and transposition of the great arteries are diagnosed prenatally versus when diagnosis of these two conditions is made only postnatally
Current and potential impact of fetal diagnosis on prevalence and spectrum of serious congenital heart disease at term in the UK. British Paediatric Cardiac Association
Prenatal diagnosis of congenital heart disease in the northern region of England: benefits of a training programme for obstetric ultrasonographers
A prospective study of the risk of congenital defects associated with maternal obesity and diabetes mellitus
Evaluation of prenatal diagnosis of congenital heart diseases by ultrasound: experience from 20 European registries
Does advanced ultrasound equipment improve the adequacy of ultrasound visualization of fetal cardiac structures in the obese gravid woman?
The impact of maternal obesity on midtrimester sonographic visualization of fetal cardiac and craniospinal structures
Trends in prenatal diagnosis, pregnancy termination, and perinatal mortality of newborns with congenital heart disease in France, 1983-2000: a population-based evaluation
Prevalence and prenatal diagnosis of congenital malformations in the Parisian population: twenty years of surveillance by the Paris Registry of congenital malformations
The examiner's ultrasound experience has a significant impact on the detection rate of congenital heart defects at the second-trimester fetal examination
Immediate and long-term outcomes in children with prenatal diagnosis of selected isolated congenital heart defects
The hidden mortality of transposition of the great arteries and survival advantage provided by prenatal diagnosis
Influence of ultrasonographers training on prenatal diagnosis of congenital heart diseases: a 12-year population-based study
Impact of prenatal diagnosis of transposition of the great arteries on obstetric and early postnatal management
Diagnosis of congenital heart disease in a nonselected population in Upper Normandy: retrospective study between 2003 and 2007
Impact of a regional training program in fetal echocardiography for sonographers on the antenatal detection of major congenital heart disease
Prenatal diagnosis of transposition of the great arteries over a 20-year period: improved but imperfect
Can Ultrasound in Early Gestation Improve Visualization of Fetal Cardiac Structures in Obese Pregnant Women?
Is Fetal Intelligent Navigation Echocardiography Helpful in Screening for d-Transposition of the Great Arteries?
Perinatal and early postnatal outcomes for fetuses with prenatally diagnosed d-transposition of the great arteries: a prospective cohort study assessing the effect of standardised prenatal consultation
Feasibility and Accuracy of Early Fetal Echocardiography Performed at 13+0-13+6 Weeks in a Population with Low and High Body Mass Index: a Prospective Study.
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