Jun 23, 2012

Transposons and integrons in colistin-resistant clones of Klebsiella pneumoniae and Acinetobacter baumannii with epidemic or sporadic behaviour

Journal of Medical Microbiology
Sonia Marina ArduinoDaniela Centrón

Abstract

Multiple transposons, integrons and carbapenemases were found in Klebsiella pneumoniae colistin-resistant isolates as well as a genomic resistance island of the AbaR type in Acinetobacter baumannii colistin-resistant isolates from different hospitals from Buenos Aires City. PFGE analysis showed a polyclonal dissemination of antimicrobial resistance mechanisms among K. pneumoniae isolates, while in A. baumannii isolates the epidemic clone 1 from South America was found. Resistance determinants associated with horizontal gene transfer are contributing to the evolution to pandrug resistance in both epidemic and sporadic clones.

Mentioned in this Paper

Gene Expression Regulation, Bacterial
Acinetobacter calcoaceticus
Genome
Epidemic
Colistin
Amorphophallus baumannii
Klebsiella pneumoniae
Infection by Klebsiella Pneumoniae in Conditions Classified Elsewhere and of Unspecified Site
Integrons
Acinetobacter Infections

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