Transrectal prostate biopsy sepsis rate following reduced quinolone antibiotic prophylaxis from six doses to single dose

ANZ Journal of Surgery
Haider K BangashDickon Hayne

Abstract

This study aimed to evaluate the rates of infective complication related to transrectal prostate biopsy (TRPB) as our centre changed its protocol from six doses over 3 days to a single pre-procedure prophylactic dose. This prospective cohort study identified infective complication in patients who attended and subsequently underwent TRPB at the time of their one-stop prostate clinic at our public tertiary hospital between August 2011 and April 2017. Patients who underwent TRPB between August 2011 and November 2014 received six doses of 500 mg of ciprofloxacin, taken twice daily over 3 days. This protocol was changed to a single dose of 500 mg of ciprofloxacin prior to biopsy from February 2015 to April 2017. Patients who had travelled to South East Asia in the 6 months prior to TRPB received a single dose of 1 g intravenous ertapenem prior to biopsy, and this remained unchanged throughout the study period. The rates of infective complication were recorded and compared between the groups of patients who had undergone six doses versus a single dose of prophylactic ciprofloxacin. A total of 766 patients underwent TRPB from August 2011 to April 2017. Of these, 357 patients received the 3-day course of prophylaxis (Group 1) and 409 p...Continue Reading

References

Feb 19, 2008·The Journal of Urology·J Stuart WolfUNKNOWN Urologic Surgery Antimicrobial Prophylaxis Best Practice Policy Panel
Mar 16, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Deborah A WilliamsonJoshua T Freeman
Jul 27, 2014·The Journal of Urology·Franck BruyèrePatrick Coloby
Apr 22, 2015·The Journal of Urology·Paul R WombleUNKNOWN Michigan Urological Surgery Improvement Collaborative
Jul 29, 2015·BJU International·Steve P McCombieDickon Hayne
Aug 1, 2015·Urology Annals·Paul DavisJeremy Grummet

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