PMID: 8607082Apr 1, 1996Paper

Transsphenoidal adenomectomy for microprolactinomas: 10 to 20 years of follow-up

Surgical Neurology
F MassoudHugues Beauregard

Abstract

Transsphenoidal adenomectomy is an effective treatment fo r microprolactinomas. However, postoperative recurrence of hyperprolactinemia is not rare. This study was designed to evaluate the long-term outcome of women with microprolactinomas operated on by transsphenoidal approach. We retrospectively studied 64 women with microprolactinomas who underwent transsphenoidal adenomectomy and were followed for 10 to 20 years. Postoperatively, 58 women (90%) had normal plasma prolactin concentrations (<20 microg/L). After a mean of 3.3 years, during which the women were asymptomatic with normoprolactinemia, 25 (43%) had a relapse of hyperprolactinemia (> or = 20 microg/L). However, their evolution varied. Fifteen women had symptomatic hyperprolactinemia. Computed tomography (CT) scans showed recurrent microadenomas in 2 women. The other 10 women had only hyperprolactinemia. Of these women, 5 had transient hyperprolactinemia (29 +/- 4 microg/L) for 5 years, after which prolactin declined to normal 13 +/- 3 microg/L). The remaining five patients had elevated prolactin (31 +/- 3 microg/L) throughout the follow-up period (10 to 20 years). CT scan did not show recurrent adenomas in these women. Thirty-three women remained normoprolactinemic ...Continue Reading

References

Feb 1, 1989·The Journal of Clinical Endocrinology and Metabolism·J SchlechteA Luciano
Jun 1, 1986·The Journal of Clinical Endocrinology and Metabolism·J A SchlechteJ VanGilder
Nov 30, 1985·British Medical Journal·J A ThomsonD L Davies
Aug 1, 1985·The Journal of Clinical Endocrinology and Metabolism·R D JacksonW B Malarkey
Nov 1, 1984·Journal of Neurosurgery·C B Wilson
Feb 1, 1983·Neurosurgery·M H WeissC March
Dec 25, 1980·The New England Journal of Medicine·A KlibanskiJ W McArthur
Nov 26, 1994·BMJ : British Medical Journal·J A ThomsonG M Teasdale

❮ Previous
Next ❯

Citations

Aug 15, 2002·Surgical Neurology·Takumi Abe, Dieter K Lüdecke
Feb 10, 1999·Surgical Neurology·A PopadićP Komminoth
Apr 20, 1999·Endocrinology and Metabolism Clinics of North America·M E Molitch
Feb 13, 2001·Acta Obstetricia Et Gynecologica Scandinavica·P TouraineF Kuttenn
Aug 2, 2002·American Journal of Clinical Oncology·Seyfettin KöklüIbrahim Güllü
Jul 26, 2012·Systematic Reviews·Amy T WangMohammad Hassan Murad
Jun 1, 1999·Journal of Neurosurgery·R GuieuH Rochat
Aug 21, 2002·Journal of Neurosurgery·Arun P AmarMartin H Weiss
Dec 24, 2005·Journal of Endocrinological Investigation·M J BarahonaS M Webb
Dec 1, 2009·Best Practice & Research. Clinical Endocrinology & Metabolism·Annamaria Colao
Feb 9, 2016·Expert Opinion on Drug Safety·Renata S AuriemmaAnnamaria Colao
Jul 26, 2000·Baillière's Best Practice & Research. Clinical Endocrinology & Metabolism·J Webster
Apr 20, 2002·Arquivos de neuro-psiquiatria·Oswaldo Inácio TellaPaulo Henrique Aguiar
May 28, 2005·Neurosurgery·Pietro MortiniMassimo Giovanelli
May 18, 2006·Endocrine Reviews·Mary P GillamAnnamaria Colao
Aug 1, 2018·Expert Review of Endocrinology & Metabolism·Martin J Rutkowski, Manish K Aghi
Sep 29, 2006·Expert Review of Anticancer Therapy·Kiran DevisettySteven J Chmura

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.