PMID: 3766049Sep 1, 1986Paper

Transsphenoidal microsurgery for Cushing's disease

Acta Endocrinologica
M TagliaferriP Loli

Abstract

The study shows the results of transsphenoidal microsurgery in 23 patients with Cushing's disease (CD). Out of the 21 patients with tumour confined to the sella, 18 who had selective adenomectomy, and 1 who underwent total hypophysectomy had correction of hypercortisolism. None of the patients with extrasellar extension of the tumour was cured. In 2 cases no adenoma was found intra-operatively. Post-operative hypoadrenalism was documented in all the patients who remitted clinically. By 3-26 months after surgery, adequate cortisol secretion was found in 12 patients, nine of whom regained diurnal variation of cortisol secretion and ten cortisol responsiveness to hypoglycaemia; a normal or near normal response of cortisol to CRF was documented in 11 out of 17 patients tested. Thyroid and gonadal function was restored in all but two patients in clinical remission, whereas GH responsiveness to hypoglycaemia appeared impaired in 11. Two patients had recurrence of the disease 2 and 3 years, respectively, after successful adenomectomy. In our experience transsphenoidal selective adenomectomy is an effective treatment for most patients with CD; additional therapeutic approaches should be considered for patients bearing pituitary tumours...Continue Reading

Citations

Aug 1, 1997·Surgical Oncology·P J Yeh, J W Chen
Oct 1, 1990·Clinical Endocrinology·M D LittleyM L Sutton
Jul 1, 1997·Journal of Endocrinological Investigation·A ColaoG Lombardi
Nov 7, 2008·Clinical Neurology and Neurosurgery·Abtin TabaeeTheodore H Schwartz
Jan 1, 1993·Clinical Endocrinology·D R McCanceA B Atkinson
Jun 1, 1991·Clinical Endocrinology·A B Atkinson
Nov 4, 2000·Journal of Neurosurgery·J M SheehanE R Laws
Sep 1, 1993·Clinical Endocrinology·D R McCanceA B Atkinson
Jan 5, 2008·Journal of Neurosurgery·Bernd Markus HofmannRudolf Fahlbusch
Apr 5, 2011·Neurosurgical Focus·Christoph P HofstetterTheodore H Schwartz
Jun 13, 2015·Endocrine Reviews·Rosario PivonelloAnnamaria Colao
Jan 22, 1998·The Journal of Clinical Endocrinology and Metabolism·L S BlevinsG T Tindall

❮ Previous
Next ❯

Related Concepts

Related Feeds

Addison Disease

Addison's disease, also known as primary adrenal insufficiency and hypocortisolism, is a long-term endocrine disorder in which the adrenal glands do not produce enough steroid hormones. Discover the latest research on Addison's disease here.