Transsphenoidal pituitary surgery via the endoscopic technique: results in 35 consecutive patients with Cushing's disease

European Journal of Endocrinology
R T Netea-MaierA R M M Hermus

Abstract

The endoscopic technique has been recently introduced in the field of transsphenoidal pituitary surgery. This technique allows inspection of sellar, supra- and parasellar structures and removal of the tumor under direct visualization, is minimally traumatic and permits easier reoperations. This is the first report on the results of endoscopic surgery for patients with Cushing's disease. Our aim was to retrospectively analyze the results of pituitary surgery in 35 consecutive patients with Cushing's disease operated in our hospital after the introduction of the endoscopic technique (1998-2004). Remission was defined as suppression of plasma cortisol (< or =50 nmol/L) after 1 mg dexamethasone overnight determined in the first 3 months after surgery and disappearance of clinical signs and symptoms of hypercortisolism. The patients were followed for an average of 27 months (range 4 to 81 months, median 20 months). Pituitary MRI showed a macroadenoma in 6 patients, a microadenoma in 17 patients and no adenoma in 12 patients. After the initial surgery 27 patients (77%) were in remission. None of the patients had a relapse during follow-up. In the remaining 8 patients hypercortisolemia persisted after surgery. Three of them had a seco...Continue Reading

Citations

Nov 16, 2013·Neurosurgical Review·Mustafa BerkerAlper Gürlek
Jul 31, 2012·The Journal of Clinical Endocrinology and Metabolism·A H van LieropS E Papapoulos
Jun 4, 2013·Journal of Neurosurgery·Kunal S PatelTheodore H Schwartz
Nov 29, 2012·Journal of Neurosciences in Rural Practice·Yr YadavPr Bhatele
Apr 22, 2014·Neurocirugía·Juan Antonio Simal-JuliánCarlos Botella-Asunción
Mar 23, 2010·Acta neurochirurgica·Erik J van LindertJ André Grotenhuis
Apr 23, 2013·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Hussein AlahmadiKalman Kovacs
Apr 24, 2009·Acta neurochirurgica·Michael Powell
May 11, 2010·Acta neurochirurgica·Neil L Dorward
Oct 9, 2012·Neurosurgery Clinics of North America·Sameer A ShethBrooke Swearingen
Aug 9, 2011·Otolaryngologic Clinics of North America·Rataphol Chris DhepnorraratDharambir Singh Sethi
Jul 25, 2009·Endocrinología y nutrición : órgano de la Sociedad Española de Endocrinología y Nutrición·Cristina Lamas Oliveira, Javier Estrada García
Dec 18, 2008·ANZ Journal of Surgery·Erik Kent WeitzelPeter-John Wormald
Jun 6, 2015·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Elena García-GarrigósMaria Dolores Guirau-Rubio
Aug 28, 2014·Case Reports in Neurological Medicine·Cesare ZoiaPaolo Gaetani
Oct 2, 2014·Surgical Endoscopy·Fuyu WangGuochen Sun
Mar 4, 2015·Endocrinology and Metabolism Clinics of North America·Robert F Dallapiazza, John A Jane
Sep 20, 2016·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Maria FleseriuUNKNOWN AACE Neuroendocrine and Pituitary Scientific Committee *
Jan 23, 2008·Arquivos brasileiros de endocrinologia e metabologia·Guilherme RollinMauro A Czepielewski
Jan 23, 2008·Arquivos brasileiros de endocrinologia e metabologia·Mauro A CzepielewskiNelson P Ferreira
Jul 5, 2017·Internal Medicine Journal·Timothy M E DavisNeville Knuckey
Dec 18, 2012·Journal of Neurology, Neurosurgery, and Psychiatry·Mario AmmiratiIvan Ciric
Jun 13, 2015·Endocrine Reviews·Rosario PivonelloAnnamaria Colao
Apr 7, 2011·Arquivos brasileiros de endocrinologia e metabologia·Erika Ribeiro BarbosaJulio Abucham
Oct 18, 2007·Current Opinion in Endocrinology, Diabetes, and Obesity
Oct 18, 2007·Current Opinion in Endocrinology, Diabetes, and Obesity

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.