PMID: 7372609May 25, 1980Paper

Transsulfuration by human long term lymphoid lines. Normal and cystathionase-deficient cells.

The Journal of Biological Chemistry
J A SturmanG E Gaull

Abstract

Long term human lymphoid cells from normal subjects were able to convert [35S]homocysteine to [35S]-cystine. The labeled cystine was found incorporated into proteins. Cells cultured from a patient with vitamin B6-unresponsive cystathioninuria, which contain no measurable cystathionase activity, were unable to perform this conversion. This is the first direct demonstration of transsulfuration by diploid cells in culture.

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