Transthoracic Doppler echocardiography to noninvasively assess coronary vasoconstrictor and dilator responses in humans.

American Journal of Physiology. Heart and Circulatory Physiology
Afsana MomenLawrence I Sinoway

Abstract

Human studies of coronary circulation are limited because of methodological issues. Recently, a noninvasive transthoracic duplex ultrasound (TTD) technique has emerged as an important tool to measure coronary blood flow velocity (CBV) in conscious humans. We employed two protocols to determine whether noninvasive "native" coronary artery velocity responses to constrictor or dilator stimuli assessed by TTD provide reliable data. In the first protocol, coronary vascular resistance (CVR = diastolic blood pressure/CBV) responses to static handgrip were examined in the left internal mammary artery (LIMA) and native left anterior descending artery (LAD) into which the graft was inserted (patient age 63 +/- 3 years). Our prior report documented increased CVR in the LIMA graft during static handgrip (Momen et al., J Appl Physiol 102: 735-739, 2007). We hypothesized that the magnitude of increases in CVR during handgrip would be similar in the LIMA graft and LAD in the same individual. Percent increases in CVR were similar in the LIMA and distal native LAD (27 +/- 4% vs. 28 +/- 6%). In the second protocol, we studied six patients (age 61 +/- 3 years) who underwent cardiac catheterization of the LAD. We compared coronary vasodilator resp...Continue Reading

References

Sep 1, 1981·Basic Research in Cardiology·J C LonghurstJ H Mitchell
Oct 10, 2002·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Yoshiki UenoAkira Soma
Oct 28, 2006·Journal of Applied Physiology·Afsana MomenLawrence I Sinoway

❮ Previous
Next ❯

Citations

Oct 18, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Zhaohui GaoKevin D Monahan
Feb 22, 2012·American Journal of Physiology. Heart and Circulatory Physiology·Matthew D MullerLawrence I Sinoway
Sep 24, 2011·Journal of Applied Physiology·Matthew D MullerLawrence I Sinoway
Dec 28, 2010·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·R NerlaF Crea
Feb 13, 2015·Heart·Vasiliki Manou-StathopoulouRupert P Williams
Jun 3, 2017·Journal of Applied Physiology·Stephan R MamanMatthew D Muller
Mar 31, 2018·American Journal of Physiology. Heart and Circulatory Physiology·Tyler D VermeulenGlen E Foster
May 13, 2014·American Journal of Physiology. Heart and Circulatory Physiology·Matthew D MullerLawrence I Sinoway
Sep 3, 2010·The Journal of Physiology·Afsana MomenLawrence I Sinoway
Dec 7, 2013·Journal of Applied Physiology·Zhaohui GaoUrs A Leuenberger
Jan 21, 2014·American Journal of Physiology. Heart and Circulatory Physiology·Matthew D MullerLawrence I Sinoway

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.