PMID: 16613349Apr 15, 2006Paper

Transthoracic fine-needle aspiration vs concurrent core needle biopsy in diagnosis of intrathoracic lesions: a retrospective comparison of diagnostic accuracy

American Journal of Clinical Pathology
Yun GongCesar A Moran

Abstract

To assess the value and limitations of fine-needle aspiration (FNA) and core needle biopsy (CNB) in the diagnosis of intrathoracic lesions, we retrospectively compared the diagnostic accuracy of 362 FNA and concurrent CNB procedures performed on 350 patients. Based on the final diagnoses that were determined based on combined information from biopsy, resection, clinical, radiologic, and microbiologic findings, the study cases were grouped into 188 malignant, 161 benign, and 13 inconclusive lesions. FNA and CNB yielded similar diagnostic accuracy for malignant tumors (85.1% vs 86.7%) and epithelial malignant neoplasms (86.4% vs 85.2%), whereas CNB yielded better diagnostic accuracy (96%) than FNA (77%) for nonepithelial malignant neoplasms. Combined FNA and CNB substantially improved the rate of malignancy diagnosis (95.2%). Of 161 benign cases, 50 were proven to be benign-specific lesions; FNA provided specific diagnosis in 20 (40%) and CNB in 46 (92%). The remaining 111 benign lesions yielded benign-nonspecific findings on both specimens. These results indicate that CNB should be obtained when clinical or radiologic findings do not match the cytologic findings or nonepithelial lesions and benign lesions are considered likely.

Citations

Nov 9, 2010·Cardiovascular and Interventional Radiology·Randy R SibbittArthur D Bankhurst
Mar 28, 2016·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Vania TacherThierry De Baère
Dec 19, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Vladimir KravtsovDebora Kidron
Apr 25, 2016·European Radiology·W J HeerinkM Oudkerk
Mar 3, 2009·Gastrointestinal Endoscopy·Lieke P V BergerMark F J Stolk
Jan 11, 2012·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Sanjay Mukhopadhyay
Oct 21, 2010·Diagnostic Cytopathology·Namita J Gupta, Helen H Wang
Jan 26, 2011·The Cancer Journal·Sandra C Tomaszek, Dennis A Wigle

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