Transthyretin amyloidosis and two other aging-related amyloidoses in an aged vervet monkey

Veterinary Pathology
S NakamuraK Terao

Abstract

An aged male vervet monkey showed severe cardiac arrhythmia for more than 3 years. A multifocal amyloid consisting of transthyretin was deposited in all areas of the heart wall, especially in the extracellular stroma among muscle fibers and external tunica of arterioles. Moreover, the amyloid was deposited in the stroma and arterioles of other systemic organs except the liver and spleen. These characteristics are consistent with senile systemic amyloidosis in humans. A second amyloid consisting of amyloid beta protein was in senile plaques and cerebral amyloid angiopathy in the cerebral cortex. A third amyloid consisting of islet amyloid polypeptide was deposited in islets of the pancreas. Apolipoprotein E and amyloid P component colocalized with the 3 amyloids. Thus, 3 different aging-related amyloids were found in an aged vervet monkey. In particular, to our knowledge, this is the first report on spontaneous transthyretin amyloidosis in animals.

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Citations

Dec 4, 2009·Reproduction : the Official Journal of the Society for the Study of Fertility·Nobuhiro ShimozawaTadashi Sankai
Jan 16, 2010·The Journal of Veterinary Medical Science·James Kenn ChambersYumi Une
Jul 14, 2009·Journal of Comparative Pathology·H HataiT Umemura
Dec 21, 2011·Laboratory Investigation; a Journal of Technical Methods and Pathology·Mitsuharu UedaYukio Ando
May 19, 2012·Circulation Research·Steven R HouserUNKNOWN American Heart Association Council on Basic Cardiovascular Sciences, Council on Clinical Cardiology, and Council on Function
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Apr 20, 2019·Frontiers in Physiology·Ridwan Babatunde IbrahimJin-Wu Tsai

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Methods Mentioned

BETA
X-ray

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