PMID: 8938268Feb 9, 1996Paper

Transthyretin gene in Alzheimer's disease patients

Neuroscience Letters
Joana Almeida PalhaMaria João Saraiva

Abstract

Amyloid beta (Abeta) is known to be the main component of Alzheimer's disease (AD) senile plaques. A homologous peptide is a normal component of biological fluids and is called soluble Abeta (sAbeta). Synthetic peptides homologous to Abeta form amyloid-like fibrils in vitro. This fibril formation can be inhibited by normal human cerebrospinal fluid (CSF) [Wisniewski et al., Ann. Neurol. 34 (1993)]. Furthermore, it has been proposed that normal transthyretin (TTR), which is a component of CSF, can itself bind sAbeta, preventing amyloid fibril formation, and that variants of TTR could be associated with AD [Schwarzman et al., Proc. Natl. Acad. Sci. USA, 91 (1994)]. Because of this possible association, we screened for TTR mutations from 47 sporadic and 19 early-onset familial AD patients using single strand conformation polymorphism analysis. Our results show no correlation between TTR variants and Alzheimer's disease in this group of patients.

References

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Citations

Jan 30, 2003·Clinical Chemistry and Laboratory Medicine : CCLM·Joana Almeida Palha
Feb 27, 2003·Proceedings of the National Academy of Sciences of the United States of America·Ann B Goodman, Arthur B Pardee
Mar 31, 2009·Neurobiology of Aging·Karen T CuencoUNKNOWN MIRAGE Study Group
May 16, 2006·Neurobiology of Aging·João Carlos SousaJoana Almeida Palha
Mar 11, 2004·Journal of Neurochemistry·João Carlos SousaJoana Almeida Palha
Jan 3, 2001·Microscopy Research and Technique·A Chodobski, J Szmydynger-Chodobska
Sep 25, 2015·Journal of Alzheimer's Disease : JAD·Melissa A Bradley-WhitmanMark A Lovell
Mar 22, 2020·International Journal of Molecular Sciences·Tiago GiãoIsabel Cardoso
Aug 26, 2021·Alzheimer's Research & Therapy·Tiago GiãoIsabel Cardoso
Oct 24, 2013·Molecular Neurodegeneration·Fernanda MarquesJoana Almeida Palha

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