Transthyretin Stabilization: An Emerging Strategy for the Treatment of Alzheimer's Disease?

International Journal of Molecular Sciences
Federica SaponaroGrazia Chiellini

Abstract

Transthyretin (TTR), previously named prealbumin is a plasma protein secreted mainly by the liver and choroid plexus (CP) that is a carrier for thyroid hormones (THs) and retinol (vitamin A). The structure of TTR, with four monomers rich in β-chains in a globular tetrameric protein, accounts for the predisposition of the protein to aggregate in fibrils, leading to a rare and severe disease, namely transthyretin amyloidosis (ATTR). Much effort has been made and still is required to find new therapeutic compounds that can stabilize TTR ("kinetic stabilization") and prevent the amyloid genetic process. Moreover, TTR is an interesting therapeutic target for neurodegenerative diseases due to its recognized neuroprotective properties in the cognitive impairment context and interestingly in Alzheimer's disease (AD). Much evidence has been collected regarding the neuroprotective effects in AD, including through in vitro and in vivo studies as well as a wide range of clinical series. Despite this supported hypothesis of neuroprotection for TTR, the mechanisms are still not completely clear. The aim of this review is to highlight the most relevant findings on the neuroprotective role of TTR, and to summarize the recent progress on the de...Continue Reading

References

Jan 1, 1991·Acta Neuropathologica·H Braak, E Braak
Feb 1, 1990·The American Journal of Physiology·G SchreiberM B Segal
Apr 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·P WestermarkG G Cornwell
Jun 1, 1989·The Journal of Clinical Endocrinology and Metabolism·S L MunroJ R Stockigt
Jan 1, 1989·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·B JacobssonA Carlström
Apr 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·M KatoD S Goodman
Nov 1, 1974·Endocrinology·G A Hagen, L A Solberg
May 1, 1968·Clinica Chimica Acta; International Journal of Clinical Chemistry·R StabiliniR P Agostoni
Sep 1, 1968·The Journal of Clinical Investigation·M KanaiD S Goodman
Apr 19, 1984·The New England Journal of Medicine·D S Goodman
Oct 1, 1983·The American Journal of Medicine·G G CornwellP Pitkänen
Sep 26, 1995·Proceedings of the National Academy of Sciences of the United States of America·C D Link
Aug 30, 1994·Proceedings of the National Academy of Sciences of the United States of America·A L SchwarzmanP K Coyle
Jan 1, 1996·Ciba Foundation Symposium·A L Schwarzman, D Goldgaber
Feb 1, 1997·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·G Schreiber, S J Richardson
Oct 29, 1997·Journal of Neurology, Neurosurgery, and Psychiatry·J M SerotM Couturier
Oct 6, 2000·General and Comparative Endocrinology·D M PowerC R Santos
Oct 19, 2000·The Journal of Biological Chemistry· van Bennekum AMW S Blaner
Nov 6, 2001·Cellular and Molecular Life Sciences : CMLS·J A Hamilton, M D Benson
Jan 25, 2003·European Journal of Biochemistry·Therese EneqvistA Elisabeth Sauer-Eriksson
Jan 30, 2003·Clinical Chemistry and Laboratory Medicine : CCLM·Joana Almeida Palha
Aug 1, 1958·Endocrinology·S H INGBAR
Jan 9, 2004·Journal of Medicinal Chemistry·Sara L Adamski-WernerJeffery W Kelly
Feb 18, 2004·Laboratory Investigation; a Journal of Technical Methods and Pathology·Sean R MillerJeffery W Kelly
Mar 11, 2004·Journal of Neurochemistry·João Carlos SousaJoana Almeida Palha
Mar 23, 2004·The Journal of Biological Chemistry·Márcia Almeida LizMónica Mendes Sousa
Sep 16, 2005·The Journal of Biological Chemistry·Philippe MarambaudPeter Davies
Nov 4, 2006·Science·Michel Goedert, Maria Grazia Spillantini
Dec 21, 2006·Biochemistry·Lin Liu, Regina M Murphy
Jan 31, 2007·Annals of the New York Academy of Sciences·Giuseppina CandoreCalogero Caruso
Mar 30, 2007·Journal of Neuroscience Research·Hye-Sun KimJoung-Hun Kim
May 22, 2007·Neurobiology of Aging·Jonathan Brouillette, Rémi Quirion
Jun 8, 2007·Muscle & Nerve·Merrill D Benson, John C Kincaid
Jun 29, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Se Hoon ChoiSangram S Sisodia
Aug 19, 2007·Journal of Lipid Research·Márcia Almeida LizMónica Mendes Sousa
Aug 19, 2007·Neurobiology of Learning and Memory·João Carlos SousaJoana Almeida Palha
Aug 19, 2007·Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis·Clement E TagoeJoel N Buxbaum
Sep 28, 2007·Journal of Neurochemistry·Carolina E FlemingMónica M Sousa
Feb 15, 2008·Proceedings of the National Academy of Sciences of the United States of America·Joel N BuxbaumTamas Bartfai

❮ Previous
Next ❯

Citations

Jul 3, 2021·International Journal of Molecular Sciences·Grazia Chiellini
Jul 30, 2021·Acta Neurologica Scandinavica·Hacer DurmuşYeşim Gülşen Parman
Aug 24, 2021·Journal of Alzheimer's Disease : JAD·Feifei GeJingping Shi

❮ Previous
Next ❯

Methods Mentioned

BETA
electrophoresis
X-ray
transgenic
ELISA
antisense oligonucleotides
antisense oligonucleotide

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.