Transtympanic perfusion: indications and limitations

Current Opinion in Otolaryngology & Head and Neck Surgery
Joshua P Light, Herbert Silverstein

Abstract

To review the most recent literature regarding the application of transtympanic inner ear perfusion in the treatment of inner ear disorders including Meniere disease, sudden sensorineural hearing loss, and autoimmune inner ear disease. The use of gentamicin perfusion in the management of Meniere disease with intractable vertigo has been demonstrated to have a very high rate of success, and is much less invasive than alternative surgical procedures such as vestibular nerve section or labyrinthectomy. The technique for achieving the highest rate of success while still minimizing the risk of cochleotoxicity continues to be investigated. Sustained delivery techniques such as the Silverstein MicroWick appear to achieve the best pharmacokinetic profile within the inner ear fluids. The end point of treatment does not necessarily require complete vestibular ablation to cure the patient, and shorter courses of treatment may help to reduce the risk of hearing loss. Cochlear Meniere disease can be treated with dexamethasone 4 mg/cc perfusion of the inner ear, which may improve the hearing, tinnitus, and pressure in the ear. Sudden sensorineural hearing loss has been managed with transtympanic steroid delivery, and this appears to be benef...Continue Reading

References

Jul 1, 1977·The Annals of Otology, Rhinology, and Laryngology·D E Mattox, F B Simmons
Aug 1, 1973·Acta Oto-laryngologica·H F SchuknechtP M Naufal
Jan 23, 1999·The Laryngoscope·N B BikhaziM I Singer
Mar 20, 2001·Archives of Otolaryngology--head & Neck Surgery·C AlexiouK Lamm
Apr 21, 2001·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·S S Chandrasekhar
Jul 13, 2001·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·R D KopkeR L Jackson
Sep 14, 2001·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·G J Gianoli, J C Li
Nov 17, 2001·Annals of the New York Academy of Sciences·M E HofferD Wester
Sep 28, 2002·The Laryngoscope·Zoran BecvarovskiMichael J LaRouere
Nov 20, 2002·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Stefan K R PlontkeAlec N Salt
Dec 19, 2002·Otolaryngologic Clinics of North America·Lance E Jackson, Herbert Silverstein
Mar 7, 2003·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Joshua P LightLance E Jackson
Apr 19, 2003·Acta Oto-laryngologica·Larbi ChelikhVincent Couloigner
Apr 23, 2003·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Nechama UriElhanan Greenberg
Jun 24, 2003·The Journal of Laryngology and Otology·R J Obholzer, M J Wareing
Sep 16, 2003·The Laryngoscope·Kamil Muzaffar
Jul 1, 1956·The Laryngoscope·H F SCHUKNECHT
Sep 23, 2003·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Chu-Yao ChenSteven D Rauch
Sep 23, 2003·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Eduardo Martin, Nicolas Perez
Nov 7, 2003·The Laryngoscope·Todd M HillmanDouglas A Chen
Dec 5, 2003·The Annals of Otology, Rhinology, and Laryngology·Boris Olivier WesterlakenFrans Willem Jan Albers
Feb 3, 2004·The Laryngoscope·Todd A HillmanMoises A Arriaga
Feb 18, 2004·The Journal of Otolaryngology·Chris DiamondRichard Liu

❮ Previous
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Citations

Dec 3, 2009·Ear and Hearing·Andrew A McCallMichael J McKenna
Sep 2, 2008·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Anthony A MikulecAlec N Salt
Nov 20, 2009·Audiology & Neuro-otology·Alec N Salt, Stefan K Plontke
Oct 24, 2009·The Tohoku Journal of Experimental Medicine·Leonard P RybakVickram Ramkumar
Jan 18, 2013·Therapeutic Delivery·E HoskisonJ P Birchall
Jun 28, 2006·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·José Ramón García-BerrocalRafael Ramírez-Camacho
Oct 14, 2008·Advanced Drug Delivery Reviews·Erin E Leary SwanJeffrey T Borenstein
Jun 20, 2006·Cancer Treatment Reviews·J H van den BergJ H M Schellens
Dec 3, 2013·Journal of Controlled Release : Official Journal of the Controlled Release Society·David A BorkholderRobert D Frisina
Sep 21, 2012·Acta Oto-laryngologica·Adnan LidianLeif Nordang
May 9, 2006·ORL; Journal for Oto-rhino-laryngology and Its Related Specialties·Iacopo DallanBruno Fattori
Jun 22, 2006·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Arata HoriiTakeshi Kubo
Sep 18, 2008·Current Opinion in Otolaryngology & Head and Neck Surgery·David A Borkholder
Apr 23, 2014·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Amit Justin SoodTed A Meyer
Jun 8, 2011·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Hung-Pin WuPeir-Rong Chen
Aug 25, 2012·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Zhoobin A Mood, Sam J Daniel
Jul 30, 2019·Chemical Research in Toxicology·Luyu QiFuyi Wang
Jun 3, 2020·European Annals of Otorhinolaryngology, Head and Neck Diseases·P HermanS Schmerber

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