Transtympanic Ringer's lactate application in the prevention of cisplatinum-induced ototoxicity in a chinchilla animal model

Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery
Raymundo MunguiaSam J Daniel

Abstract

Ototoxicity is currently the most frequent dose-limiting side effect of cisplatinum chemotherapy. To date, there is no protocol to prevent dose-related ototoxicity, despite its prevalence and predictability. Previous animal studies have found lactate to be effective in the prevention of cisplatinum-induced ototoxicity. The objective of this study was to test the protective benefits of transtympanic Ringer's lactate in the prevention of cisplatinum-induced ototoxicity. A randomized prospective controlled trial was conducted in an animal model. Animal care research facilities of The Montreal Children's Hospital Research Institute. A total of 44 chinchillas were exposed to systemic cisplatinum injected intraperitoneally in divided cycles to reach the targeted cumulative dosage of 16 mg/kg. Ototopical application of Ringer's lactate solution 0.2 mL twice per day during the chemotherapy cycles was performed. Each animal had one experimental (Ringer's) and one control ear. Distortion product otoacoustic emissions (DPOAEs) were collected for a wide range of frequencies (between 1 and 16 kHz), and scanning electron microscopy was performed to evaluate the protective effects of Ringer's lactate. Ototopical application of Ringer's lactat...Continue Reading

References

Aug 15, 1990·Hearing Research·D McAlpine, B M Johnstone
Jan 1, 1988·Medical and Pediatric Oncology·P BrockC R Pinkerton
Jan 1, 1995·Acta Oto-laryngologica. Supplementum·R J MountR V Harrison
Nov 1, 1994·ORL; Journal for Oto-rhino-laryngology and Its Related Specialties·T Saito, J M Aran
Aug 1, 1997·Hearing Research·R V HarrisonH Hirakawa
Jun 28, 2002·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Kurtis D KorverKathleen M Campbell
Mar 8, 2003·International Journal of Pediatric Otorhinolaryngology·Masa-aki Teranishi, Tsutomu Nakashima
Oct 16, 2003·Journal of the American Academy of Audiology·Kathleen Campbell
Sep 30, 2004·Journal of Pediatric Hematology/oncology·Patrizia BertoliniOlivier Hartmann
Nov 18, 2004·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Won-Taek ChoeKay W Chang
Nov 23, 2006·Hearing Research·Leonard P RybakVickram Ramkumar
Jun 7, 2007·Journal of Pediatric Hematology/oncology·Patrícia P CoradiniAlgemir L Brunetto
Dec 20, 2007·The Laryngoscope·Sam Joseph DanielFadi Akache
Oct 1, 2004·Journal of Pediatric Hematology/oncology·Patrizia BertoliniOlivier Hartmann

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Citations

Mar 9, 2011·Neurotoxicity Research·Owen Woods, Issam Saliba
Sep 23, 2014·Expert Opinion on Investigational Drugs·Debashree MukherjeaVickram Ramkumar
Jun 1, 2012·Expert Opinion on Drug Discovery·Debashree MukherjeaSandeep Sheth
Oct 18, 2011·Expert Opinion on Drug Metabolism & Toxicology·Joshua G YorgasonFederico Kalinec
Nov 26, 2008·American Journal of Otolaryngology·Matthew W MillerFrank G Ondrey
Sep 14, 2016·International Journal of Pediatric Otorhinolaryngology·Harun Soyalıçİbrahim Aladağ

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Methods Mentioned

BETA
scanning electron microscopy
electron microscopy

Software Mentioned

Power and Precision
SmartEP

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