Transurethral biopsy of the prostate for persistently elevated or increasing prostate specific antigen following multiple negative transrectal biopsies

The Journal of Urology
E S RovnerA Wein

Abstract

Treatment of the patient with persistently elevated prostate specific antigen (PSA) levels after pathologically negative transrectal or manually directed prostate needle biopsy is unclear. We retrospectively evaluated the use of transurethral biopsy of the prostate as an adjunctive study for the diagnosis of prostate cancer in these patients. From January 1993 through February 1996, 71 patients underwent transurethral biopsy in conjunction with repeat prostatic needle biopsy for a persistently elevated PSA (greater than 4 ng./ml.) after previously negative needle biopsy. All patients had at least 1 previous ultrasound guided sextant prostatic needle biopsy (mean 1.85, range 1 to 7) with or without manually directed biopsies. Following negative prostatic needle biopsy these patients subsequently underwent a minimum of a 4-quadrant transurethral sampling of the prostatic fossa followed by repeat sextant prostatic needle biopsy. A subset of patients underwent sampling of the anterior prostatic tissue or transition zone using transrectal ultrasound guided prostatic needle biopsy at transurethral biopsy. Of the 71 patients with elevated PSA (mean 16.2 ng./ml., range 4.2 to 171) 17 (24%) had prostate cancer on the repeat prostatic ne...Continue Reading

Citations

Dec 10, 2003·Prostate Cancer and Prostatic Diseases·L GoemanH Van Poppel
Oct 21, 2004·Cancer·David G BostwickBarry Timms
Jul 25, 2018·Minerva urologica e nefrologica = The Italian journal of urology and nephrology·Ki H KimJang H Kim
Jan 24, 2004·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·David G Bostwick, Junqi Qian
Sep 1, 2006·Pathobiology : Journal of Immunopathology, Molecular and Cellular Biology·H OhmoriH Kuniyasu
Mar 22, 2000·Current Opinion in Urology·R G Aarnink, H Wijkstra

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