Transurethral light delivery for prostate photoacoustic imaging

Journal of Biomedical Optics
Muyinatu A Lediju BellEmad M Boctor

Abstract

Photoacoustic imaging has broad clinical potential to enhance prostate cancer detection and treatment, yet it is challenged by the lack of minimally invasive, deeply penetrating light delivery methods that provide sufficient visualization of targets (e.g., tumors, contrast agents, brachytherapy seeds). We constructed a side-firing fiber prototype for transurethral photoacoustic imaging of prostates with a dual-array (linear and curvilinear) transrectal ultrasound probe. A method to calculate the surface area and, thereby, estimate the laser fluence at this fiber tip was derived, validated, applied to various design parameters, and used as an input to three-dimensional Monte Carlo simulations. Brachytherapy seeds implanted in phantom, ex vivo, and in vivo canine prostates at radial distances of 5 to 30 mm from the urethra were imaged with the fiber prototype transmitting 1064 nm wavelength light with 2 to 8 mJ pulse energy. Prebeamformed images were displayed in real time at a rate of 3 to 5 frames per second to guide fiber placement and beamformed offline. A conventional delay-and-sum beamformer provided decreasing seed contrast (23 to 9 dB) with increasing urethra-to-target distance, while the short-lag spatial coherence beamf...Continue Reading

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Citations

Aug 4, 2015·Photoacoustics·Muyinatu A Lediju BellEmad M Boctor
Aug 30, 2016·Biomedical Optics Express·Haichong K ZhangEmad M Boctor
Feb 19, 2016·IEEE Transactions on Medical Imaging·Hyun Jae KangEmad M Boctor
Jun 16, 2017·Sensors·Yuqi ZhangZhen Gu
Mar 25, 2018·Journal of Biomedical Optics·Mucong LiJunjie Yao
Jun 21, 2018·Physics in Medicine and Biology·Joshua Shubert, Muyinatu A Lediju Bell
Apr 11, 2019·Journal of Biomedical Optics·Paul Kumar Upputuri, Manojit Pramanik
Aug 30, 2019·Science Translational Medicine·Sri-Rajasekhar KothapalliSanjiv S Gambhir
Mar 21, 2019·Biomedical Optics Express·Brittani BungartJi-Xin Cheng
Jul 1, 2020·Annals of Biomedical Engineering·Paolo ZaffinoMaria Francesca Spadea
Nov 22, 2018·Biomedical Optics Express·Brooke StephanianMuyinatu A Lediju Bell
Jul 28, 2020·Journal of Biomedical Optics·Eduardo A Gonzalez, Muyinatu A Lediju Bell
Nov 21, 2020·Journal of Biomedical Optics·Corey KellySeptimiu E Salcudean
Dec 19, 2020·Molecular Imaging·Mucong LiJunjie Yao
May 18, 2021·Biomedical Optics Express·Alycen Wiacek, Muyinatu A Lediju Bell

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