PMID: 8972794Dec 1, 1996Paper

Transurethral microwave thermotherapy v sham treatment: double-blind randomized study

Journal of Endourology
M L BluteD K Hellerstein

Abstract

Transurethral microwave thermotherapy (TUMT) is a single-session, 1-hour office-based treatment for benign prostatic hyperplasia. A randomized, double-blind study has been conducted at our institutions involving 115 patients who, after satisfying the entry criteria, were randomized in a 2:1 fashion to receive TUMT or a sham treatment. Three months' unblinding revealed both statistically and clinically significant improvement in the efficacy measures for the real treatment compared with the sham. The mean Madsen Symptom Score decreased 55% and the mean peak flow rate increased 58% in the TUMT-treated patients v 28% and 27% in the sham-treated patients (P < 0.001). Also, the TUMT-treated patients improved in mean AUA Symptom Score by 43% v 26% for sham-treated patients (P < 0.01). Reclassification of patients after therapy showed a greater shift to the mild category of AUA Symptom Score: 37% for TUMT patients v 6.5% for sham-treated patients. In addition, prostate-specific antigen elevation to >4 times baseline was noted 1 week after TUMT v no statistically significant change for sham-treated patients. This double-blind study demonstrates that thermotherapy's efficacy is not placebo related and that the mechanism of action is rel...Continue Reading

References

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Citations

Dec 26, 2001·Urology·M L Blute, T Larson
May 16, 2002·International Journal of Urology : Official Journal of the Japanese Urological Association·Takashi OhigashiMasaru Murai
Apr 23, 2002·BJU International·T JakubczykZ Dobrowolski
Jan 10, 2003·BJU International·B DjavanM Marberger
Nov 18, 2000·Journal of Endourology·M Brehmer, S Baba
Nov 18, 2000·Journal of Endourology·M J de WildtT Eliasson
Nov 18, 2000·Journal of Endourology·W J Lynch, S F Graber
Dec 24, 2010·Critical Reviews in Biomedical Engineering·Christopher L Brace
Jun 11, 1998·Mayo Clinic Proceedings·M L BluteB F King
Oct 13, 2006·Current Opinion in Urology·S MadersbacherM Marberger
Apr 10, 2002·Journal of Advanced Nursing·Sonia M Junqueira V OliveiraJair Licio F Santos
Sep 14, 2012·The Cochrane Database of Systematic Reviews·Richard M HoffmanTimothy J Wilt
Dec 20, 2002·Current Opinion in Urology·Jason S OgisteSteven A Kaplan
Aug 28, 2021·The World Journal of Men's Health·Juan Victor Ariel FrancoPhilipp Dahm
Nov 26, 2021·BJU International·Juan Victor Ariel FrancoPhilipp Dahm

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