Transvaginal sling using acellular human dermal allograft: safety and efficacy in 253 patients

The Journal of Urology
S CrivellaroJ F Bresette

Abstract

We evaluated the safety and efficacy of using human dermal allograft material for transvaginal slings to treat female stress urinary incontinence (SUI). We present a prospective series of 253 patients with SUI treated with a transvaginal sling using a Repliform cadaveric human dermal allograft (LifeCell Corp., The Woodlands, Texas) and a bone anchor fixation kit. Clinical history, urogynecologic examination and videourodynamics were performed preoperatively. Results were assessed by a third party through validated quality of life questionnaires (Incontinence Impact Questionnaire and Urogenital Distress Inventory), overall impression and percent of improvement as perceived by the patients, and pad use. Scheduled followup examination were performed to rule out erosion, infection, obstruction, pain or recurrent incontinence. Complete followup was available on 234 of 253 patients. Average followup was 18 months. Of the patients 78% were cured or improved according to the questionnaires. The average improvement was 80%. At 18 months of followup incontinence average distress and scores decreased 10 and 7 points, respectively. Complications were de novo urgency in 5% of cases, recurrent SUI in 15% with no cases of persistent SUI, rete...Continue Reading

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Citations

Sep 24, 2005·Neurourology and Urodynamics·Kathleen C Kobashi, Fred Govier
Jul 2, 2009·International Urogynecology Journal and Pelvic Floor Dysfunction·John T StoffelJohn F Bresette
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Jun 2, 2005·Current Opinion in Urology·Jason P Gilleran, Philippe Zimmern

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