Transvaginal ultrasound studies of vascular and morphological changes in uteri exposed to diethylstilbestrol in utero

Human Reproduction
Bruno SalleR C Rudigoz

Abstract

The aim of this prospective study was to establish complementary data of uteri exposed to diethylstilbestrol (DES) in utero for transvaginal analysis and vascularity changes during the menstrual cycle. A total of 28 women with DES-exposed uteri were compared with 60 non-exposed women. Transvaginal ultrasound and colour Doppler imaging were performed on days 5 and 22 of the menstrual cycle. Uteri were measured on sagittal and transverse scans. Uterine length, width, thickness and uterine cavity length and width were measured. Uterine volume and uterine cavity area were calculated. DES-exposed uterine volume was equal to 31.84 +/- 3.37 cm3. The cavity area of DES-exposed uterus was equal to 35.85 +/- 3.93 cm2. Cervix length of DES-exposed uterus was significantly smaller than that of non-exposed uterus. The uterine artery pulsatility index (PI) of DES-exposed uterus was significantly higher than that of normal uterus. Blood flow remained stable throughout the menstrual cycle. The PI of DES-exposed uterus remained stable during the menstrual cycle, as in non-exposed uterus, and it decreased during the luteal phase. This lack of modification in vascularity of DES-exposed uterus may explain miscarriages and obstetric complications s...Continue Reading

Citations

Jul 9, 2004·Toxicology and Applied Pharmacology·Kimberly P MillerJodi A Flaws
Jul 31, 1999·Fertility and Sterility·J M Goldberg, T Falcone
Feb 24, 2006·Journal of Perinatal Medicine·Sonia S HassanYoram Sorokin
Aug 20, 2004·Radiology·Robert N Troiano, Shirley M McCarthy
Jul 9, 2013·Journal of Mid-life Health·Shikha SethGarima Gupta
Oct 16, 2012·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Spencer C BehrAliya Qayyum
Aug 16, 2014·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Roberto RomeroYeon Mee Kim
Nov 19, 2004·Neoplasia : an International Journal for Oncology Research·Gilbert SchönfelderIbrahim Chahoud
Mar 14, 2009·The Australian & New Zealand Journal of Obstetrics & Gynaecology·Madhu BagariaKiran Mishra
Sep 9, 2006·Gynécologie, obstétrique & fertilité·Olivier GarbinC Rongières

Related Concepts

Arteries
Cervix Uteri
Distilbène
Ovarian Cycle
Prenatal Exposure Delayed Effects
Pulsatile Flow
Uterus
Ultrasonography, Doppler, Color

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