May 21, 2004

Transverse craniofacial features and their genetic predisposition in families with nonsyndromic unilateral cleft lip and palate

The Cleft Palate-craniofacial Journal : Official Publication of the American Cleft Palate-Craniofacial Association
Young-Jooh YoonStephanos Kyrkanides

Abstract

The purpose of this study was to evaluate the transverse craniofacial form in families with nonsyndromic cleft lip and palate (NSCLP). It was hypothesized that affected as well as noncleft NSCLP family members are characterized by a common array of craniofacial features that differ from the general population. This was a prospective cross-sectional investigation that included affected children with NSCLP and their noncleft parents and siblings. A total of 114 subjects (14 affected girls, 17 affected girls, 15 unaffected male siblings, 10 unaffected female siblings, 29 unaffected biological mothers, and 29 unaffected biological fathers) were included. Subject records comprised of posteroanterior cephalometric radiographs obtained from all 114 subjects. The width of midfacial structures, including the orbit and nose, was increased in NSCLP families, compared with published norms. Interestingly, the face was disproportionally wider in relation to total facial height. The transverse craniofacial form of children with or without clefts significantly correlated with that of their parents. Mothers displayed strong correlation with their affected and unaffected sons, whereas fathers correlated to their daughters, suggesting a possible ...Continue Reading

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Citations

Mentioned in this Paper

Prevalence Studies
Sister
Plain X-ray
Cleft Palate, Isolated
Calvaria
Genetic Inheritance
Craniometry
Intraobserver Variation
Step-parent
Maxillofacial Development

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