PMID: 3737274May 1, 1986Paper

Trapped gas and airflow limitation in children with cystic fibrosis and asthma

Pediatric Pulmonology
K DesmondP H Beaudry

Abstract

Trapped gas (TG) has been shown to be present in cystic fibrosis (CF) and asthma, but its relationship with airflow limitation (AL) has not been explored. TG was defined as the difference between the functional residual capacity measured by body plethysmography [FRC(BP)] and that measured by helium dilution [FRC(He)] expressed as a percentage of total lung capacity (TLC). We studied 21 children with CF and 15 with asthma who had a similar degree of AL and hyperinflation, however the children with CF had greater amounts of TG compared with asthma [15% +/- 2 (mean +/- 1 SE) vs 8 +/- 2, P less than 0.05]. Mixing efficiency (ME), an index of the distribution of ventilation, was found to be lower in the CF children than in those with asthma (34 +/- 4 vs 54 +/- 4). In CF, TG correlated with forced expiratory flow between 25 and 75% of vital capacity (FEF25-75), ME, RV/TLC, and maximal expiratory flow rates at 25 and 50% of vital capacity (Vmax25 and 50, respectively; r = -0.66, -0.61, 0.72, -0.71, -0.74). ME also correlated with the above measures. In asthma, TG did not correlate with the FEF25-75, ME, RV/TLC, Vmax25, or Vmax50. Furthermore, TG was frequently found in patients with asthma with moderate AL while it was often absent in...Continue Reading

Citations

Jan 1, 1990·Pediatric Pulmonology·M S Zach
Jan 1, 1995·Pediatric Pulmonology·P K Yiallouros, A D Milner
Feb 26, 2004·Paediatric Respiratory Reviews·A L Coates
Mar 1, 1988·Archives of Disease in Childhood·J PoolJ F Price
Jul 9, 2013·Paediatric Respiratory Reviews·Harm TiddensStephanie D Davis
Mar 13, 2012·Revue des maladies respiratoires·G ReychlerP Lebecque
Sep 17, 2010·Pediatric Pulmonology·Richard Kraemer, Cindy Thamrin
Jan 19, 2010·Pediatric Pulmonology·Harm TiddensPeter D Paré
Dec 23, 2006·Pediatric Pulmonology·Per Gustafsson

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Forced Expiratory Volume Function
Plethysmography
Expiratory Airflow

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