Jan 2, 2019

Trapping a somatic endogenous retrovirus into a germline piRNA cluster immunizes the germline against further invasion

BioRxiv : the Preprint Server for Biology
Celine DucEmilie Brasset


Background: For species survival, the germline must faithfully transmit genetic information to the progeny. Transposable elements (TEs), which are major components of eukaryotic genomes, constitute a significant threat to genome stability due to their mobility. In the metazoan germline, their mobiliza-tion is limited by a class of small RNAs that are called PIWI-interacting RNAs (piRNAs) and are produced by dedicated genomic loci called piRNA clusters. Although the piRNA pathway is an adaptive genomic immunity system, it remains unclear how the germline is protected from a new transposon invasion. To address this question, we used Drosophila melanogaster lines harboring a deletion within flamenco, a major piRNA cluster that is specifically expressed in somatic follicu-lar cells. This deletion leads to derepression of the retrotransposon ZAM in the somatic follicular cells and subsequent germline genome invasion. Results: In this mutant line that express ZAM in somatic follicular cells, we identified de novo production of sense and antisense ZAM-derived piRNAs that displayed a germinal molecular signature. These piRNAs originated from a new ZAM insertion into a germline dual-strand piRNA cluster and si-lenced ZAM expression spec...Continue Reading

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Mentioned in this Paper

Biochemical Pathway
Small Nuclear RNA
Isolation Aspects
Genomic Stability
Gene Deletion
Gene Expression
Adaptive Immunity
Piwi-Interacting RNA

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