TRAPPopathies: An emerging set of disorders linked to variations in the genes encoding transport protein particle (TRAPP)-associated proteins

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Michael SacherMiroslav P Milev

Abstract

The movement of proteins between cellular compartments requires the orchestrated actions of many factors including Rab family GTPases, Soluble NSF Attachment protein REceptors (SNAREs) and so-called tethering factors. One such tethering factor is called TRAnsport Protein Particle (TRAPP), and in humans, TRAPP proteins are distributed into two related complexes called TRAPP II and III. Although thought to act as a single unit within the complex, in the past few years it has become evident that some TRAPP proteins function independently of the complex. Consistent with this, variations in the genes encoding these proteins result in a spectrum of human diseases with diverse, but partially overlapping, phenotypes. This contrasts with other tethering factors such as COG, where variations in the genes that encode its subunits all result in an identical phenotype. In this review, we present an up-to-date summary of all the known disease-related variations of genes encoding TRAPP-associated proteins and the disorders linked to these variations which we now call TRAPPopathies.

References

Mar 25, 1993·Nature·T SöllnerJ E Rothman
Dec 1, 1995·Molecular Biology of the Cell·G RossiS Ferro-Novick
Nov 1, 1996·The Journal of Cell Biology·O UllrichR G Parton
Apr 7, 1998·Cell·T WeberJ E Rothman
Dec 23, 1998·Proceedings of the National Academy of Sciences of the United States of America·D FasshauerR Jahn
Oct 19, 2000·The Journal of Cell Biology·W WangS Ferro-Novick
Mar 10, 2001·Molecular Cell·M SacherS Ferro-Novick
Apr 9, 2001·The Journal of Biological Chemistry·E S SuvorovaV V Lupashin
May 12, 2001·American Journal of Human Genetics·A K GedeonJ C Mulley
Jul 10, 2001·The Journal of Clinical Endocrinology and Metabolism·P T ChristieR V Thakker
Jan 5, 2002·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·S MummM P Whyte
Oct 4, 2002·The Journal of Biological Chemistry·Se Bok JangByung-Ha Oh
Oct 18, 2002·Traffic·Meir Aridor, Lisa A Hannan
Feb 21, 2003·Current Biology : CB·Josh DubnauTim Tully
Apr 18, 2003·The Journal of Biological Chemistry·Asish K GhoshRatna B Ray
Mar 19, 2004·The EMBO Journal·Hidenori HiroseMitsuo Tagaya
Apr 27, 2004·Nature Medicine·Xiaohua WuHudson H Freeze
May 26, 2004·Biochemical and Biophysical Research Communications·Katherine K RogersJoshua H Lipschutz

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Citations

Jul 3, 2019·The Plant Journal : for Cell and Molecular Biology·Monika KaldeFarhah F Assaad
Aug 21, 2019·The EMBO Journal·Francesca ZappaMaria Antonietta De Matteis
Dec 4, 2019·Brain : a Journal of Neurology·Nicole J Van BergenJohn Christodoulou
Sep 10, 2020·European Journal of Human Genetics : EJHG·Shereen G GhoshJoseph G Gleeson
Oct 5, 2020·Brain : a Journal of Neurology·Nicole J Van BergenJohn Christodoulou
Aug 11, 2019·FEBS Letters·Zhanna Lipatova, Nava Segev
Oct 5, 2020·Brain : a Journal of Neurology·Ahmed K SaadJames R Lupski
May 1, 2021·Genes·Maria Isabel Alvarez-MoraLaia Rodriguez-Revenga
May 22, 2021·The EMBO Journal·Aaron Mn JoinerJ Christopher Fromme
Feb 26, 2021·Molecular Plant-microbe Interactions : MPMI·Dongying LiuGehong Wei
Nov 1, 2020·Life Sciences·Cheryl Qian Ying Yong, Bor Luen Tang
Jul 7, 2021·Journal of Molecular Biology·Noah J HarrisJohn E Burke

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