Trastuzumab Deruxtecan: First Approval

Drugs
Susan J Keam

Abstract

Trastuzumab deruxtecan (ENHERTU®), a HER2-directed antibody and DNA topoisomerase I inhibitor conjugate, is being developed for the treatment of HER2-expressing solid tumours, including breast cancer, gastric cancer, colorectal cancer and non-small cell lung cancer by Daiichi Sankyo Company Ltd in collaboration with AstraZeneca. Based primarily on the results of the phase 2 DESTINY-Breast01 trial, trastuzumab deruxtecan was recently approved in the USA under accelerated approval for the treatment of adult patients with unresectable or metastatic HER2-positive breast cancer who have received two or more prior anti-HER2-based regimens in the metastatic setting. This article summarizes the milestones in the development of trastuzumab deruxtecan leading to this first approval.

References

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Citations

Aug 23, 2020·International Journal of Molecular Sciences·Alberto JuanCarlos Alonso-Moreno
Aug 17, 2020·Current Opinion in Oncology·Rita AssiAhmad Awada
Nov 21, 2020·Annals of the New York Academy of Sciences·Yueping LiuYingyong Hou
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Mar 31, 2021·Journal of Medicinal Chemistry·Andrew C FlickChristopher J O'Donnell
May 6, 2021·International Journal of Molecular Sciences·Alice IndiniFrancesco Grossi
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Jul 20, 2021·Chemical Science·Hikaru SekiDavid R Spring
May 14, 2021·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Mikiko SuzukiAkinobu Hamada
Jun 12, 2021·Clinical Pharmacology and Therapeutics·Robert B DiasioSteven M Offer
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Aug 24, 2021·Monoclonal Antibodies in Immunodiagnosis and Immunotherapy·Nami TateyamaYukinari Kato
Aug 28, 2021·Journal of Personalized Medicine·Anna BurguinFrancine Durocher
Jun 20, 2021·Cancer Research·Li-Chung TsaoZachary C Hartman

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