Trastuzumab improves tumor perfusion and vascular delivery of cytotoxic therapy in a murine model of HER2+ breast cancer: preliminary results

Breast Cancer Research and Treatment
Anna G SoraceThomas E Yankeelov

Abstract

To employ in vivo imaging and histological techniques to identify and quantify vascular changes early in the course of treatment with trastuzumab in a murine model of HER2+ breast cancer. Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) was used to quantitatively characterize vessel perfusion/permeability (via the parameter K (trans) ) and the extravascular extracellular volume fraction (v e ) in the BT474 mouse model of HER2+ breast cancer (N = 20) at baseline, day one, and day four following trastuzumab treatment (10 mg/kg). Additional cohorts of mice were used to quantify proliferation (Ki67), microvessel density (CD31), pericyte coverage (α-SMA) by immunohistochemistry (N = 44), and to quantify human VEGF-A expression (N = 29) throughout the course of therapy. Longitudinal assessment of combination doxorubicin ± trastuzumab (N = 42) tested the hypothesis that prior treatment with trastuzumab will increase the efficacy of subsequent doxorubicin therapy. Compared to control tumors, trastuzumab-treated tumors exhibited a significant increase in K (trans) (P = 0.035) on day four, indicating increased perfusion and/or vessel permeability and a simultaneous significant increase in v e (P = 0.01), indicating increase...Continue Reading

References

Sep 1, 1993·Cancer Immunology, Immunotherapy : CII·G D LewisH M Shepard
Feb 1, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Charles L VogelMichael Press
Mar 22, 2002·Nature·Yotaro IzumiRakesh K Jain
Oct 7, 2003·Oncogene·Sylvie MénardElda Tagliabue
Apr 28, 2004·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Q G de LussanetA W Griffioen
Oct 21, 2005·The New England Journal of Medicine·Edward H RomondNorman Wolmark
Oct 21, 2005·The New England Journal of Medicine·Gabriel N Hortobagyi
Mar 22, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Judith HurleyDennis J Slamon
Nov 14, 2006·Breast Cancer Research : BCR·Rita Nahta, Francisco J Esteva
Jan 11, 2007·British Journal of Cancer·J P B O'ConnorG C Jayson
Nov 22, 2008·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Windy Dean-Colomb, Francisco J Esteva
Oct 16, 2009·Current Medical Imaging Reviews·Thomas E Yankeelov, John C Gore
Nov 4, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Neil L Spector, Kimberly L Blackwell
Jul 12, 2011·Physiological Reviews·Shom GoelRakesh K Jain
Jul 23, 2011·International Journal of Cancer. Journal International Du Cancer·Yoshinori HirashimaKuniaki Shirao
Nov 3, 2011·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Christel VangestelMarc Peeters
Mar 7, 2012·Cold Spring Harbor Perspectives in Medicine·Shom GoelRakesh K Jain
May 25, 2012·Radiology·Nola M HyltonUNKNOWN ACRIN 6657 Trial Team and I-SPY 1 TRIAL Investigators
Jun 12, 2012·Cell·Rakesh K Jain, Peter Carmeliet
Jun 22, 2012·Frontiers in Oncology·Thuy Vu, Francois X Claret
Aug 1, 2012·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Stephanie L BarnesThomas E Yankeelov
Jan 22, 2013·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Erlend K F AndersenEirik Malinen
May 15, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Rakesh K Jain
Jul 19, 2014·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Jennifer G WhisenantThomas E Yankeelov
Jul 30, 2014·Biomedical Optics Express·Devin R McCormackMelissa C Skala
Jan 31, 2015·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Shahid AhmedJim Xiang

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Citations

Aug 11, 2016·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Anna G SoraceThomas E Yankeelov
Nov 9, 2017·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Ryan T WoodallThomas E Yankeelov
Mar 28, 2018·The Journal of Pharmacology and Experimental Therapeutics·Christopher S RabenderRoss B Mikkelsen
Apr 11, 2020·PloS One·Caleb M PhillipsThomas E Yankeelov
Sep 22, 2018·Mathematical Medicine and Biology : a Journal of the IMA·Angela M JarrettAnna G Sorace
Dec 11, 2017·ACS Biomaterials Science & Engineering·Jianfeng ZhangXianfeng Lin

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