Trastuzumab in the treatment of elderly patients with early breast cancer: Results from an observational study in Germany

Journal of Geriatric Oncology
Peter DallAxel Hinke

Abstract

In elderly patients with HER2-positive breast cancer, few data on efficacy and toxicity of adjuvant trastuzumab treatment exists since older patients were in general excluded from large randomized studies. This prospective observational study aimed to confirm the beneficial findings from pivotal trials in age cohorts ≥65 years. There were no restrictions for recruitment with respect to age or concomitant/sequential adjuvant medication. Long-term relapse/survival status of the patients was assessed once a year. Among the 3940 evaluable patients enrolled between 2006 and 2012 at 339 institutions, 507 were aged between 65 and 69 years, with another 507 patients ≥70 years. Elderly patients suffered from significantly more advanced primary tumors. Preceding or concomitant chemotherapy showed decreasing aggressiveness with patient's age. Trastuzumab treatment was stopped prematurely in only 11% of the elderly, but more often than in younger patients (p=0.0008). With 453 events hitherto reported, elderly patients did not exhibit an inferior relapse-free survival when adjusted for other relevant prognostic factors (hazard ratio: 1.01 per year; p=0.24). Three-year overall survival was significantly lower in the population older than 64 ...Continue Reading

References

Apr 6, 2000·Journal of the National Cancer Institute·S G DiabG M Clark
Oct 21, 2005·The New England Journal of Medicine·Martine J Piccart-GebhartUNKNOWN Herceptin Adjuvant (HERA) Trial Study Team
Oct 21, 2005·The New England Journal of Medicine·Edward H RomondNorman Wolmark
Sep 11, 2007·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·M Aapro, C D Johnson
Dec 30, 2008·Clinical Oncology : a Journal of the Royal College of Radiologists·K Tipples, A Robinson
May 5, 2009·Archives of Gerontology and Geriatrics·Ioannis E Petrakis, Stefanos Paraskakis
Jul 20, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Edith A PerezNorman Wolmark
Oct 14, 2011·The New England Journal of Medicine·Dennis SlamonUNKNOWN Breast Cancer International Research Group
Nov 10, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Benjamin D SmithThomas A Buchholz
Nov 20, 2012·Journal of the American College of Cardiology·Jersey ChenCary P Gross
Feb 27, 2013·Anti-cancer Agents in Medicinal Chemistry·M J Molina-GarridoA Mora-Rufete
May 11, 2013·Cancer Treatment Reviews·Joan AlbanellCésar A Rodríguez
Jul 23, 2013·Lancet·Aron GoldhirschUNKNOWN Herceptin Adjuvant (HERA) Trial Study Team
Feb 4, 2014·Journal of Geriatric Oncology·Rachel A Freedman, Hyman B Muss
Feb 12, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Ines Vaz-LuisRachel A Freedman
May 29, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Carlos H BarcenasSharon H Giordano
May 29, 2014·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Hyman B Muss

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Citations

Mar 25, 2016·Expert Review of Anticancer Therapy·Noam PondéHatem A Azim
Aug 20, 2016·Expert Opinion on Pharmacotherapy·Katarzyna J JerzakKathleen I Pritchard
Jun 25, 2017·The Breast : Official Journal of the European Society of Mastology·Waqar HaqueSandra Hatch
Feb 8, 2018·Current Oncology Reports·Olivia Le Saux, Claire Falandry
Oct 17, 2017·Breast Cancer Research and Treatment·Thomas FietzUNKNOWN TMK-Group (Tumour Registry Breast Cancer)
May 29, 2020·Future Oncology·Marcelle GoldnerNoam Pondé
Sep 17, 2020·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Masataka SawakiUNKNOWN RESPECT study group
Feb 11, 2018·Annals of Surgical Oncology·Anita MamtaniRanjna Sharma

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