Trastuzumab signaling in ErbB2-overexpressing inflammatory breast cancer correlates with X-linked inhibitor of apoptosis protein expression

Molecular Cancer Therapeutics
Katherine M AirdGayathri R Devi

Abstract

Inflammatory breast cancer (IBC) patients show poor survival and a significant incidence of epidermal growth factor receptor-2 (ErbB2) overexpression. A distinct mechanism involving increased expression of X-linked inhibitor of apoptosis protein (XIAP) and survivin, key members of the inhibitor of apoptosis protein (IAP) family, was observed post-trastuzumab (an ErbB2 monoclonal antibody) treatment in an ErbB2-overexpressing, estrogen receptor negative, IBC cellular model, SUM190PT, isolated from a primary IBC tumor. In contrast, a decrease in the IAP expression was observed in the non-IBC, ErbB2-overexpressing SKBR3 cells in which trastuzumab treatment also decreased p-AKT and cell viability. Further, in SUM190PT cells, therapeutic sensitivity to GW583340 (a dual epidermal growth factor receptor/ErbB2 kinase inhibitor) corresponded with XIAP down-regulation and abrogation of XIAP inhibition on active caspase-9 release. Specific small interfering RNA-mediated XIAP inhibition in combination with trastuzumab caused decrease in inactive procaspase-9 and inhibition of p-AKT corresponding with 45% to 50% decrease in cell viability in the SUM190PT cells, which have high steady-state p-AKT levels. Further, embelin, a small-molecule in...Continue Reading

References

Dec 1, 1986·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J RouësséF May-Levin
Jan 1, 1996·Recent Results in Cancer Research. Fortschritte Der Krebsforschung. Progrès Dans Les Recherches Sur Le Cancer·M Kaufmann
Aug 1, 1997·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·S D MerajverL J Pierce
Dec 22, 1999·British Journal of Cancer·F ForozanS P Ethier
Jan 27, 2000·Cell·D Hanahan, R A Weinberg
Dec 21, 2000·International Journal of Radiation Oncology, Biology, Physics·G S RaoS P Ethier
May 18, 2001·Nature·G I Evan, K H Vousden
Dec 26, 2001·Journal of the National Cancer Institute·Y LuM Pollak
Jun 14, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·William F AndersonShine Chang
Nov 25, 2003·Oncogene·Peter ListonRobert G Korneluk
Dec 3, 2003·The Journal of Biological Chemistry·Han C DanJin Q Cheng
Apr 21, 2004·Drug News & Perspectives·Gayathri R Devi
Jun 26, 2004·The Journal of Biological Chemistry·Takehiko DohiDario C Altieri
Sep 10, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Roberto GennariAlberto Costa
Dec 1, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Michele MilellaGabriella Zupi
Feb 3, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Neil L SpectorSarah Bacus
Apr 1, 2005·International Journal of Cancer. Journal International Du Cancer·Karianne E LongvaInger H Madshus
May 3, 2005·Nature Reviews. Cancer·Nancy E Hynes, Heidi A Lane
Jan 13, 2006·Annals of Oncology : Official Journal of the European Society for Medical Oncology·B M RyanM J Duffy
Jan 21, 2006·Cancer Gene Therapy·G R Devi
Feb 7, 2006·Cancer Letters·Rita Nahta, Francisco J Esteva
May 10, 2006·Proceedings of the National Academy of Sciences of the United States of America·Wenle XiaNeil L Spector
May 10, 2006·Nature Clinical Practice. Oncology·Rita NahtaFrancisco J Esteva
Sep 5, 2006·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Dang M NguyenJenny C Chang

❮ Previous
Next ❯

Citations

May 12, 2011·Breast Cancer Research and Treatment·Katherine M AirdGayathri R Devi
Mar 5, 2009·Journal of Mammary Gland Biology and Neoplasia·Philippe L BedardMartine J Piccart-Gebhart
Sep 26, 2013·European Journal of Cell Biology·Gabriela Nestal de MoraesRaquel C Maia
Jul 1, 2009·Breast Cancer Research : BCR·Fiona M FosterCharles H Streuli
Jan 24, 2013·PloS One·Smita NairGayathri R Devi
Mar 8, 2014·PloS One·Cody J WehrkampJustin L Mott
Apr 27, 2013·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Sabine M BrouxhonLi Ma
Jan 9, 2014·Expert Opinion on Investigational Drugs·Radhika Poojari
Dec 5, 2015·Frontiers in Oncology·Martin Holcik
Jul 16, 2010·The Journal of Pathology·Azhar R HussainKhawla S Al-Kuraya
Dec 20, 2014·Cell Death and Differentiation·C L BuchheitZ T Schafer
Apr 6, 2018·Future Medicinal Chemistry·Kirti S PrabhuShahab Uddin
Jun 14, 2017·Mediators of Inflammation·Riley J MorrowMatthias Ernst
Apr 18, 2012·Molecular Cancer Therapeutics·Jennifer L AllensworthGayathri R Devi

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.