Trauma-hemorrhage activates signal transduction pathways in mouse splenic T cells

Shock
T S SamyI H Chaudry

Abstract

Severe impairment in the functions of immune-competent cells has been observed following trauma and hemorrhage. Inappropriate release of cytokines during trauma and hemorrhagic shock disrupt T lymphocyte functions and enable cells to activate genes whose products are detrimental for maintaining a much-needed humoral and cell-mediated immunity. The intracellular events for gene activation are mediated by cytoplasmic transcription factors present as nascent (signal transducer and activator of transcription 1 (STAT 1)) or as a complex (nuclear factor kappaB (NF-kappaB)). Receptor-initiated phosphorylation activates these transcription factors prior to their nuclear translocation and binding to cognate DNA sequences. Because T cell functions are critical to efficient functioning of the immune system, we investigated whether expression of transcription factors, STAT1 and NF-kappaB, is perturbed in splenic T cells following trauma and hemorrhage. To study this, enriched T cells harvested from spleens (pooled from three or four mice per group) of sham, trauma (consisting of midline laparotomy), sham+trauma, hemorrhage (blood pressure maintained at approximately 30 mmHg for 90 min followed by adequate fluid resuscitation), and trauma+h...Continue Reading

Citations

Jul 19, 2008·Shock·Takeshi Tsukamoto, Hans Christoph Pape
Jul 29, 2004·Journal of Cellular Physiology·Michelle AlexanderMartin G Schwacha
Apr 28, 2006·Journal of Cellular Physiology·Tanjanika DanielMartin G Schwacha
Aug 1, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Shaolong YangIrshad H Chaudry
Mar 28, 2003·American Journal of Physiology. Cell Physiology·T S Anantha SamyIrshad H Chaudry
May 9, 2002·American Journal of Physiology. Cell Physiology·Rui ZhengIrshad H Chaudry
Feb 10, 1999·The American Journal of Physiology·M K AngeleI H Chaudry
Feb 9, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Y MizushimaI H Chaudry

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