Trauma-shock-induced gut injury and the production of biologically active intestinal lymph is abrogated by castration in a large animal porcine model

Shock
Edwin A DeitchDa-Zhong Xu

Abstract

Although small animal rodent studies indicate that there is a sexual dimorphism in the resistance to organ injury after trauma-hemorrhagic shock (T/HS), confirmatory studies are largely lacking in more clinically relevant large animal species. Thus, we tested the hypothesis that castration would reduce the susceptibility of adult minipigs to gut injury and abrogate the production of biologically active intestinal (mesenteric) lymph after T/HS. The hemodynamic response to T/HS was similar between castrated and noncastrated minipigs. Mesenteric lymph collected during the preshock period and in the trauma-sham shock (T/SS) animals did not have increased biological activity. However, T/HS-lymph from the noncastrated males increased the respiratory burst of normal neutrophils, increased endothelial cell monolayer permeability, and was cytotoxic for endothelial cells. Castration abrogated the T/HS-induced neutrophil-activating and endothelial-injurious activities of mesenteric lymph, and the biological activity of the T/HS-lymph from the castrated minipigs was not different from the T/SS animals. As compared with the T/SS minipigs, T/HS increased ileal mucosal injury and intestinal permeability. This increase in gut permeability afte...Continue Reading

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Feb 12, 2002·Shock·Da-Zhong XuEdwin A Deitch
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Feb 6, 2004·Critical Care Medicine·Edwin A DeitchDa Zhong Xu
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Apr 18, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Edwin A DeitchCarl J Hauser

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Citations

Dec 21, 2011·World Journal of Gastrointestinal Pathophysiology·Stelios F AssimakopoulosAristidis Charonis
Mar 27, 2010·The Journal of Membrane Biology·Cleyton C DominguesGiampaolo Minetti
Jul 17, 2008·Shock·Stephen F Lowry
Sep 30, 2009·The British Journal of Surgery·I H Chaudry, K I Bland

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