Traumatic brain axonal injury produces sustained decline in intracellular free magnesium concentration

Brain Research
D L Heath, R Vink

Abstract

Decline in brain intracellular free magnesium concentration following experimental traumatic brain injury has been widely reported in a number of studies. However, to date, these studies have been confined to focal models of brain injury and temporally limited to the immediate 8-h period post-trauma. Recently, a new model of impact-acceleration brain injury has been developed which produces nonfocal diffuse axonal injury more typical of severe clinical trauma. The present study has used phosphorus magnetic resonance spectroscopy and the rotarod motor test to characterise magnesium homeostasis and neurologic outcome over a period of 8 days after induction of severe impact-acceleration injury in rats. Severe impact-acceleration induced injury resulted in a highly significant and sustained decline in intracellular free magnesium concentration that was apparent for 4 days post-trauma with recovery to preinjury levels by day six. There were no significant changes in pH or ATP concentration at any time point post-injury. All animals demonstrated a significant neurologic deficit over the assessment period. The extended period of magnesium decline after severe diffuse brain trauma suggests that repeated administration may be required f...Continue Reading

References

Jan 1, 1991·Annual Review of Physiology·Z S Agus, M Morad
May 7, 1990·Biochimica Et Biophysica Acta·L BirnbaumerA M Brown
Feb 1, 1986·Annals of Neurology·S M Rothman, J W Olney
Mar 20, 1989·Brain Research·T K McIntoshA I Faden
Nov 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·M Terasaki, H Rubin
Mar 1, 1988·Journal of Neurosurgery·E D HallJ M Braughler
May 1, 1980·Journal of Clinical Chemistry and Clinical Biochemistry. Zeitschrift Für Klinische Chemie Und Klinische Biochemie·H Ebel, T Günther
Jun 1, 1995·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·G D Williams, M B Smith
Sep 1, 1994·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·J P HeadrickR Vink
Feb 1, 1994·Journal of Neurosurgery·M A Foda, A Marmarou
Jan 1, 1994·Journal of the Society for Gynecologic Investigation·M HallakD B Cotton

❮ Previous
Next ❯

Citations

Feb 5, 2010·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Robert Vink, Corinna van den Heuvel
Jul 18, 2003·Clinica Chimica Acta; International Journal of Clinical Chemistry·Serdar KahramanErdener Timurkaynak
Nov 13, 2001·Clinical and Experimental Pharmacology & Physiology·R VinkI Cernak
Sep 30, 1998·Journal of Neurotrauma·D H SmithR E Lenkinski
Oct 22, 2005·Journal of Neurotrauma·Andrew O KoobRichard B Borgens
Mar 15, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Nicolás Palacios-PradoFeliksas F Bukauskas
May 24, 2006·Brain Research Bulletin·Adrianne B Barbre, Michael R Hoane
Apr 3, 2001·Expert Opinion on Investigational Drugs·A I Maas
Oct 22, 2002·Expert Opinion on Investigational Drugs·Robert Vink, Alan J Nimmo
Oct 6, 2004·Expert Opinion on Investigational Drugs·Robert Vink, Corinna Van Den Heuvel
May 20, 1998·Scandinavian Journal of Clinical and Laboratory Investigation·D L Heath, R Vink
Mar 29, 2001·The Journal of Head Trauma Rehabilitation·W M BrooksC Gasparovic
Aug 24, 2012·Current Opinion in Anaesthesiology·Dhuleep S WijayatilakePeter B Sherren
Jan 12, 2013·The Physician and Sportsmedicine·Joseph C MaroonJeffrey W Bost
Jul 22, 2019·Journal of Molecular Modeling·Juan M R AlbanoMonica Pickholz
Apr 15, 2003·Neuroreport·Huguette C Politi, Robin R Preston
Feb 15, 2021·Neuro-Chirurgie·S WalrandM Abbot
Nov 28, 2020·The American Journal of Emergency Medicine·Louis StandifordChristopher Trigger
Jul 22, 2008·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·D L Heath, R Vink

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain Injury & Trauma

brain injury after impact to the head is due to both immediate mechanical effects and delayed responses of neural tissues.