Traumatic brain injury accelerates kindling epileptogenesis in rats

Neurological Research
Mansoureh EslamiMahmoudreza Hadjighassem

Abstract

Traumatic brain injury (TBI) is a well-known cause of symptomatic epilepsy. In animal models of post-traumatic epilepsy (PTE), progression of trauma to epilepsy takes several weeks to months. Although this long process is similar to clinical PTE, it is costly and laborious. We used a combination of TBI and kindling as an accelerated animal model to develop epilepsy in much shorter period compared to that occurring in PTE. Traumatic brain injury was exerted to parieto-temporal cortex of anaesthetised rats by controlled cortical impact (CCI, 5 mm round tip, 4.5 mm/seconds velocity and 150 ms duration). Chemical kindling started 24 hours after CCI by intraperitoneal injection of 30 mg/kg pentylenetetrazole (PTZ) every other day until manifestation of three consecutive generalised seizures. Rapid electrical kindling of the amygdala began 1 week after TBI by exertion of 12 daily threshold stimuli (50 Hz mono-phasic square-wave stimulus of 1 ms per wave for 3 seconds) with 5 minutes interval between each stimulation until the rats became kindled. Controlled cortical impact injury accelerated rate of both chemical and electrical kindling. Number of PTZ injections required for acquisition of generalised seizures decreased from 13.1 ± 1...Continue Reading

References

Jan 1, 1991·Progress in Neurobiology·E W LothmanJ L Stringer
Mar 1, 1972·Electroencephalography and Clinical Neurophysiology·R J Racine
Mar 1, 1993·Epilepsy Research·E W Lothman, J M Williamson
Aug 17, 2002·Brain : a Journal of Neurology·M C WalkerJ W A S Sander
Jan 4, 2006·NeuroRx : the Journal of the American Society for Experimental NeuroTherapeutics·Ibolja Cernak
Jun 21, 2013·Frontiers in Cellular Neuroscience·Robert F HuntBret N Smith
Feb 18, 2014·Epilepsy & Behavior : E&B·Asla PitkänenTamuna Bolkvadze

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Citations

Dec 1, 2015·Journal of Neuroimmunology·Mansoureh EslamiMahmoudreza Hadjighassem
Jun 10, 2017·Journal of Anatomy·Zuzanna SetkowiczKrzysztof Janeczko
Dec 2, 2017·Journal of Neuroscience Research·Eric J NeubergerVijayalakshmi Santhakumar
Nov 17, 2017·The Journal of Pharmacology and Experimental Therapeutics·Shu-Hui Chuang, Doodipala Samba Reddy
Jan 10, 2020·Neurological Research·Mansoureh EslamiMohammad Sayyah
Jun 20, 2020·Journal of Neuroinflammation·Sanjib MukherjeeLee A Shapiro
May 26, 2021·Epilepsia Open·Jesús-Servando Medel-MatusAndrey Mazarati

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