PMID: 26899581Feb 24, 2016Paper

Traumatic Brain Injury as a Risk Factor for Alzheimer's Disease: Is Inflammatory Signaling a Key Player?

Current Alzheimer Research
Jelena DjordjevicBenedict C Albensi

Abstract

Traumatic brain injury (TBI) has become a significant medical and social concern within the last 30 years. TBI has acute devastating effects, and in many cases, seems to initiate long-term neurodegeneration. With advances in medical technology, many people are now surviving severe brain injuries and their long term consequences. Post trauma effects include communication problems, sensory deficits, emotional and behavioral problems, physical complications and pain, increased suicide risk, dementia, and an increased risk for chronic CNS diseases, such as Alzheimer's disease (AD). In this review, we provide an introduction to TBI and hypothesize how it may lead to neurodegenerative disease in general and AD in particular. In addition, we discuss the evidence that supports the hypothesis that TBI may lead to AD. In particular, we focus on inflammatory responses as key processes in TBI-induced secondary injury, with emphasis on nuclear factor kappa B (NF-κB) signaling.

Citations

Nov 9, 2018·Alzheimer's & Dementia : Translational Research & Clinical Interventions·Jefferson W KinneyBruce T Lamb
Aug 3, 2020·European Journal of Trauma and Emergency Surgery : Official Publication of the European Trauma Society·José Luís AlvesAnabela Mota Pinto
Feb 13, 2020·International Journal of Molecular Sciences·Fabiana NovellinoGiuseppe Donato
Aug 23, 2019·Molecular Therapy. Nucleic Acids·Li Zhang, Handong Wang
Dec 29, 2020·Chinese Journal of Traumatology = Zhonghua Chuang Shang Za Zhi·Xiao-Jian XuBai-Yun Liu
Apr 10, 2021·Frontiers in Neuroscience·Michael K GhiamMichael E Hoffer
Jul 30, 2021·Ageing Research Reviews·Doortje W DekensPetrus J W Naudé

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