PMID: 18427091DOI: 10.1503/cmaj.080282Apr 23, 2008Paper
Traumatic brain injury: can the consequences be stopped?
CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne
Eugene ParkAndrew J Baker
Abstract
Traumatic brain injury is a leading cause of morbidity and death in both industrialized and developing countries. To date, there is no targeted pharmacological treatment that effectively limits the progression of secondary injury. The delayed progression of deterioration of grey and white matter gives hope that a meaningful intervention can be applied in a realistic timeframe following initial trauma. In this review we discuss new insights into the subcellular mechanisms of secondary injury that have highlighted numerous potential targets for intervention.
References
Nov 1, 1992·Chemical Research in Toxicology·W H KoppenolJ S Beckman
Aug 1, 1991·Archives of Biochemistry and Biophysics·R RadiB A Freeman
Jul 1, 1989·Histopathology·J H AdamsD R McLellan
Jun 1, 1988·Journal of Neurosurgery·J Sahuquillo-BarrisM Rodriguez-Pazos
Post-traumatic diffuse axonal brain injury. Analysis of 78 patients studied with computed tomography
Jan 1, 1986·Acta neurochirurgica·F CordobésE Lamas
Sep 1, 1995·Trends in Pharmacological Sciences·C P Taylor, B S Meldrum
Jan 1, 1995·Acta Neuropathologica·S M GentlemanD I Graham
Jan 1, 1993·Acta Neuropathologica·W L MaxwellT A Gennarelli
Jan 1, 1994·Acta Neuropathologica·F E SherriffS Wilson
Apr 16, 1996·Proceedings of the National Academy of Sciences of the United States of America·K E SaatmanT K McIntosh
Dec 1, 1995·Journal of Neurocytology·W L MaxwellT A Gennarelli
Apr 1, 1997·Neuroscience·R PosmanturR L Hayes
Jul 1, 1997·Journal of Neurotrauma·W L MaxwellD L Graham
Jun 27, 1998·Biochemical and Biophysical Research Communications·E Carafoli, M Molinari
Aug 15, 1998·Archives of Biochemistry and Biophysics·K K WangH Allen
Aug 26, 1998·The Journal of Biological Chemistry·K K WangJ S Morrow
Apr 10, 1999·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·D O Okonkwo, J T Povlishock
Apr 15, 1999·Neuroreport·D O OkonkwoJ T Povlishock
May 4, 1999·Journal of Neurotrauma·W L MaxwellD I Graham
Jul 3, 1999·Journal of Neurotrauma·A BükiJ T Povlishock
Aug 11, 1999·Trends in Neurosciences·U DirnaglM A Moskowitz
Oct 16, 1999·Journal of Neurotrauma·E McCrackenD Dewar
Jan 12, 2000·Free Radical Research·B HalliwellM Whiteman
Jan 13, 2000·Trends in Neurosciences·K K Wang
Feb 15, 2000·The Journal of Head Trauma Rehabilitation·D J ThurmanJ E Sniezek
Feb 13, 2001·Resuscitation·S R Finfer, J Cohen
Aug 23, 2001·Trends in Molecular Medicine·Y Huang, K K Wang
Sep 27, 2001·World Journal of Surgery·A BassoN Ferrari
Sep 27, 2001·World Journal of Surgery·D F Kelly, D P Becker
Feb 21, 2002·Journal of Neurotrauma·Edward J GabrielUNKNOWN Brain Trauma Foundation
Mar 23, 2002·Science·Eric C BeattieRobert C Malenka
Jun 4, 2002·Journal of Neurotrauma·A J BakerG F Tian
Oct 26, 2002·Science·Michelle AartsMichael Tymianski
Jan 25, 2003·Journal of Neurotrauma·Syed M AhmedEarl F Ellis
May 6, 2003·Biochemical and Biophysical Research Communications·Jae-Sung KimJohn J Lemasters
Jun 25, 2003·Journal of Neurotrauma·A BukiJ T Povlishock
Oct 7, 2003·Neuromolecular Medicine·Douglas H SmithTracy K McIntosh
Oct 22, 2003·Journal of Neurosurgery·Chantal W P M HukkelhovenAndrew I R Maas
Nov 5, 2003·Arquivos de neuro-psiquiatria·Sebastião Nataniel Silva Gusmão, José Eymard Homem Pittella
Jan 30, 2004·Journal of Neurotrauma·Mark ArundineMichael Tymianski
Feb 28, 2004·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Christopher J FredericksonMath P Cuajungco
Feb 28, 2004·Journal of Neurotrauma·Theresa A LusardiDavid F Meaney
Mar 23, 2004·Current Molecular Medicine·S L Sensi, J-M Jeng
Apr 13, 2004·Oncogene·Xavier SaelensPeter Vandenabeele
Apr 16, 2004·Journal of Rehabilitation Medicine·J David CassidyUNKNOWN WHO Collaborating Centre Task Force on Mild Traumatic Brain Injury
Jun 29, 2004·Lancet·Charles MockFrederick Rivara
Jul 16, 2004·Journal of Neurotrauma·Paulette B GoforthLeslie S Satin
Aug 12, 2004·Radiology·Pamela W SchaeferLee H Schwamm
Sep 17, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Mark ArundineMichael Tymianski
Sep 21, 2004·Journal of Bioenergetics and Biomembranes·Valina L Dawson, Ted M Dawson
❮ Previous
Next ❯
Citations
May 28, 2010·Annals of Biomedical Engineering·Mark T BegoniaLakiesha N Williams
Sep 25, 2009·Cellular and Molecular Neurobiology·Panagiota MiltiadousFotini Stylianopoulou
Sep 26, 2012·Cellular and Molecular Neurobiology·Jian XuZhiwei Gao
Feb 2, 2013·Journal of Molecular Histology·Wei LiuJie Zhang
Jun 12, 2012·Journal of Molecular Neuroscience : MN·Casandra M CartagenaJitendra R Dave
Jan 1, 2010·International Journal of Emergency Medicine·Denis H J Caro
Oct 7, 2009·Journal of Neurotrauma·Peethambaran ArunAryan M A Namboodiri
Dec 15, 2010·Journal of Neurotrauma·Eugene ParkAndrew J Baker
May 4, 2011·Journal of Neurotrauma·Anna VilaltaMithilesh Dronavalli
Jul 21, 2011·Journal of Neurotrauma·Eleni SiopiMehrnaz Jafarian-Tehrani
Jun 5, 2013·Journal of Neurotrauma·Aziz S AlaliAvery B Nathens
Aug 14, 2012·Neuromodulation : Journal of the International Neuromodulation Society·Mauricio Fernando VillamarRoss Zafonte
Sep 17, 2013·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Kerry RennieMahmud Bani-Yaghoub
Feb 25, 2011·Journal of Neurophysiology·Paulette B GoforthLeslie S Satin
Feb 7, 2009·Critical Care : the Official Journal of the Critical Care Forum·Monika HolbeinJohn F Stover
Feb 19, 2013·Stem Cells Translational Medicine·Panagiota MiltiadousFotini Stylianopoulou
Oct 3, 2013·Journal of Neurotrauma·Gregory R HookMark S Kindy
Feb 18, 2014·Neurochemistry International·Wei ChenWan-Fu Xie
Dec 11, 2013·Molecular Neurobiology·Ping ZhengTerence J O'Brien
Jul 16, 2014·Surgical Neurology International·Wendy A Morley, Stephanie Seneff
Sep 26, 2013·Neurocritical Care·Aziz S AlaliAvery B Nathens
Dec 3, 2013·Physiology & Behavior·Irena LavrnjaVerica Milosevic
May 14, 2014·Experimental Brain Research·Daniel D KuryloFarhan Bukhari
Jun 25, 2014·Journal of Neurotrauma·Devin W McBrideDevin K Binder
Sep 18, 2014·ACS Chemical Neuroscience·Xingzhou Zhang, Jin-Song Bian
Jun 6, 2009·European Journal of Emergency Medicine : Official Journal of the European Society for Emergency Medicine·Giorgio BerlotAdriano Rinaldi
Oct 4, 2013·Shock·Wolfgang G JungerEileen M Bulger
Mar 9, 2010·Journal of Neurosurgery·Amandip S GillDevin K Binder
Aug 1, 2009·Cell Death and Differentiation·J D BellA J Baker
Jun 2, 2009·Brain Injury : [BI]·Necat BiberF Gul Dulger
Feb 24, 2016·Frontiers in Systems Neuroscience·Fady GirgisJonathan P Miller
Jul 31, 2013·Surgery·John O HwabejireHasan B Alam
Feb 27, 2016·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Vigneswaran VeeramuthuDharmendra Ganesan
Jan 15, 2013·World Neurosurgery·Michael V DeFazioM Ross Bullock
Dec 8, 2015·Neuroscience Letters·Taha KelestemurErtugrul Kilic
Nov 7, 2012·Journal of Safety Research·Victor G CoronadoLikang Xu
Aug 14, 2012·Resuscitation·Jeffrey RandallDavid H Wilson
May 10, 2012·Drug Discovery Today·Aruni S Arachchige DonX F Steven Zheng
May 24, 2011·World Neurosurgery·Mohamed El-Fiki
Mar 15, 2011·Aggression and Violent Behavior·Jianghong Liu
Dec 30, 2015·Glia·Paraskevi N KoutsoudakiRebecca Matsas
Jul 11, 2013·Science China. Life Sciences·LiZhen WangYuBo Fan
Sep 15, 2015·The Journal of Surgical Research·Bardiya ZangbarTerence O'Keeffe
Jan 1, 2010·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Hong-Cai Wang, Yan-Bin Ma
Oct 9, 2015·Scandinavian Journal of Immunology·Lijun YangZ Fan
Feb 18, 2014·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Nigel H GreigChaim G Pick
Oct 25, 2011·Journal of Neurochemistry·James A Andrews, Kameran D Neises
Jan 26, 2012·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Pedro S PintoThierry A G M Huisman
Mar 31, 2016·Zebrafish·Victoria McCutcheonAndrew J Baker
Mar 10, 2015·Neurological Research·Craig WinterStephen Rose
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Next ❯
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