Traumatic Brain Injury, Chronic Traumatic Encephalopathy, and Alzheimer's Disease: Common Pathologies Potentiated by Altered Zinc Homeostasis

Journal of Alzheimer's Disease : JAD
Stuart D Portbury, Paul A Adlard

Abstract

Alzheimer's disease, traumatic brain injury, and chronic traumatic encephalopathy represent conditions that have a profound socioeconomic impact for both the individual and the wider community. They are all characterized by specific protein aggregation that results in synaptic dysfunction, neuronal death, and consequent cognitive decline and memory loss. In this review, we present evidence to support the notion that the common pathologies found in all conditions, and indeed their associated cognitive deficits, may be linked by zinc (Zn²⁺) ion dyshomeostasis. Elucidation of this hypothesis may present new therapeutic avenues for these devastating conditions.

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Citations

Dec 26, 2015·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Atsushi Takeda, Haruna Tamano
Feb 9, 2017·Metallomics : Integrated Biometal Science·Stuart D PortburyPaul A Adlard
Dec 23, 2015·Metallomics : Integrated Biometal Science·Stuart D PortburyPaul A Adlard
Jun 7, 2018·Metallomics : Integrated Biometal Science·Stuart D PortburyPaul A Adlard
Feb 14, 2017·Israel Journal of Chemistry·Jacob M GoldbergStephen J Lippard
Aug 25, 2017·PloS One·Stuart D PortburyPaul A Adlard
Dec 7, 2018·Brain Injury : [BI]·S D PortburyP A Adlard
Sep 30, 2020·Pharmaceuticals·Pooyan KhalighinejadA Dean Sherry

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