Traumatic brain injury-induced hypopituitarism in adolescence

Pituitary
Roberto BaldelliGianni Bona

Abstract

Childhood hypopituitarism may be present at birth or may be acquired. Young children and teenagers are particularly susceptible to TBI; in fact TBI is one of the first causes of death and disability in children older than one month of age since the most common cause of TBI is car crashes, including pedestrian-car and bicycle-car encounters, falls, child abuse, violence and sports injuries. Furthermore younger kids are more likely to have TBI due to falls while teenagers have more TBI than any other population from motor vehicle crashes. As reported for the adult patients hypopituitarism in adolescence should be suspected within an appropriate clinical context. In adolescents affected by TBI no experience about this condition has been reported but it is well known that treatment of hypopituitarism, in particular of GH deficiency, has multiple beneficial effects in addition to its promotion of linear growth and in particular in the transition phase. These include maintenance of normal body composition, structure function and metabolism through adult life. Therefore, the onset of TBI-induced GH deficiency in this particular phase of life should be strictly evaluated and corrected for the possible adult health consequences.

References

Feb 1, 1995·Endocrine Reviews·H de BoerE A Van der Veen
May 7, 1998·Endocrine Reviews·S M ShaletB M Brennan
May 22, 1998·Archives of Physical Medicine and Rehabilitation·A ColantonioB A McLellan
Jul 22, 1998·Lancet·S W LambertsA J van der Lely
Apr 19, 2000·The Journal of Clinical Endocrinology and Metabolism·S BenvengaF Trimarchi
May 17, 2000·Journal of Pediatric Surgery·S ValadkaA Dueck
Sep 26, 2000·The Journal of Trauma·R BenoitS Fakhry
Oct 14, 2000·Ryōikibetsu shōkōgun shirīzu·T Mitsuma, Y Hirooka
Jun 9, 2001·The Journal of Clinical Endocrinology and Metabolism·S A LiebermanR J Urban
Aug 8, 2002·Pediatrics·Mary E AitkenJames M Robbins
May 9, 2003·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·G CorneliG Aimaretti
Aug 13, 2003·Child and Adolescent Psychiatric Clinics of North America·Ernesto Caffo, Carlotta Belaise
May 12, 2004·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Richard Stanhope
Dec 31, 2004·The Journal of Trauma·David P Mooney, Peter Forbes
Jan 8, 2005·Journal of Endocrinological Investigation·F F CasanuevaUNKNOWN Athens TBI and Hypopituitarism Study Group
Mar 11, 2005·Archives of Physical Medicine and Rehabilitation·Felipe F CasanuevaMiklós I Góth
Mar 12, 2005·The Journal of Trauma·Andrea L WinthropEvelyn M Kuhn
Jun 7, 2005·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·V PopovicE Ghigo
Sep 13, 2005·Journal of Adolescence·Christopher J DuffySusan M Moore

❮ Previous
Next ❯

Citations

Jul 17, 2007·Current Opinion in Pediatrics·Silvia Einaudi, Claudia Bondone
Aug 28, 2010·The Journal of Pediatrics·Anne-Marie D KaulfersSusan R Rose
Nov 7, 2015·Behavioural Neurology·Jhon Alexander Moreno, Michelle McKerral
Jun 20, 2007·Brain Injury : [BI]·Fateme SalehiMichael Cusimano
Mar 31, 2019·Pituitary·Aydin SavKalman Kovacs

❮ Previous
Next ❯

Related Concepts

Related Feeds

Brain Injury & Trauma

brain injury after impact to the head is due to both immediate mechanical effects and delayed responses of neural tissues.